Results 41 to 50 of about 117,876 (267)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Context Aware Middleware Architectures: Survey and Challenges
Sensors, 2015 Context aware applications, which can adapt their behaviors to changing environments, are attracting more and more attention. To simplify the complexity of developing applications, context aware middleware, which introduces context awareness into the ...
Xin Li +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Relational Structure-Aware Knowledge Graph Representation in Complex Space
Mathematics, 2022 Relations in knowledge graphs have rich relational structures and various binary relational patterns. Various relation modelling strategies are proposed for embedding knowledge graphs, but they fail to fully capture both features of relations, rich ...
Ke Sun +6 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Assessing the Sustainability Performance of Sustainability Management Software
Technologies, 2018 Companies have made considerable progress in assessing the sustainability of their processes and products, including the information and communication technology (ICT) sector.
Eva Kern, Samanthi Silva, Achim Guldner
doaj +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
SoftwareArchitecture principles affect a software system holistically. Given their alignment with a business strategy, they should be incorporated within the validation process covering aspects of sustainability. However, current research discusses the influence
Markus Funke +3 more
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Investigating Software Standards: A Lens of Sustainability for Software Crowdsourcing
IEEE Access, 2018 Inevitably, the time has come that necessitates software systems to have long lasting social impact and environmental friendliness. Although sustainability related to environmental and social aspects have been well versed in the literature, software ...
Muhammad Noman Malik, Huma Hayat Khan
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source