Results 41 to 50 of about 126,020 (260)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Process for Monitoring the Impact of Architecture Principles on Sustainability: An Industrial Case Study

Software
Architecture principles affect a software system holistically. Given their alignment with a business strategy, they should be incorporated within the validation process covering aspects of sustainability. However, current research discusses the influence
Markus Funke, Patricia Lago, Roberto Verdecchia, Roel Donker   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Green DevOps: A Strategic Framework for Sustainable Software Development

Computer Sciences & Mathematics Forum
In the era of digital transformation, the environmental impact of software development has become a pressing concern, necessitating the integration of sustainability into software development processes.
Mohamed Toufik Ailane, Carolin Rubner, Andreas Rausch   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Sustainability-centric integration software requirements validation [PDF]

MATEC Web of Conferences
Software Development Life Cycle (SDLC) is enriched with different phases. Requirement Analysis is predominant in designing and developing the software application with proper functionality and to produce expected outcome.
Kandukuri Prabhakar, Syma Kumar Dasari N.V., Ramesh G., Kativarapu Prathima   +3 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Software sustainability of global impact models [PDF]

Geoscientific Model Development
Research software for simulating Earth processes enables the estimation of past, current, and future world states and guides policy. However, this modelling software is often developed by scientists with limited training, time, and funding, leading to ...
E. Nyenah, P. Döll, P. Döll, D. S. Katz, R. Reinecke   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mapping the Research Software Sustainability Space [PDF]

2018 IEEE 14th International Conference on e-Science (e-Science), 2018
5 pages, 3 figures, 1 table, accepted as a long paper for the 9th International Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE6.1), co-locating with IEEE eScience ...
Stephan Druskat, Daniel S. Katz
openaire   +2 more sources