Results 71 to 80 of about 6,415,956 (313)

Raising awareness for potential sustainability effects in Uganda: A survey-based empirical study [PDF]

, 2019
Copyright © 2019 for this paper by its authors. In July 2019, we ran the 3rd International BRIGHT summer school for Software Engineering and Information Systems at the Makerere University in Kampala, Uganda.
Bainomugisha, E., Chaudron, M., Dearden, Andrew, Duboc, L., Hebig, R., Kanagwa, B., Okello, D., Penzenstadler, B., Umuhoza, E.   +8 more
core  

Mapping the Research Software Sustainability Space [PDF]

IEEE International Conference on e-Science, 2018
A growing number of largely uncoordinated initiatives focus on research software sustainability. A comprehensive mapping of the research software sustainability space can help identify gaps in their efforts, track results, and avoid duplication of work ...
Stephan Druskat, D. Katz
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Mind the Gap: Bridging the Sustainable Software Systems Research Divide [PDF]

, 2015
Sustainability is a major concern to humanity as a result of the consequences of the rapid consumption of the planets finite natural resources, combined with exponential economic and population growth.
Becker, Christoph, Betz, Stefanie, Chitchyan, Ruzanna, Duboc, Leticia, Easterbrook, Steve, Penzenstadler, Birgit, Rodriguez-Navas, Guillermo, Seyff, Norbert, Venters, Colin   +8 more
core  

Software Sustainability

, 2016
The Dutch Digital Heritage Network (NDE) and the Netherlands Coalition for Digital Preservation (NCDD) consist of partners in a number of sectors: science, archiving, libraries, art and broadcasting. In all these sectors the NDE and NCDD members are faced with many different aspects of software obsolescence, in agreement with the rapidly growing ...
openaire   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Summary of the First Workshop on Sustainable Software for Science: Practice and Experiences (WSSSPE1) [PDF]

, 2014
Challenges related to development, deployment, and maintenance of reusable software for science are becoming a growing concern. Many scientists’ research increasingly depends on the quality and availability of software upon which their works are built ...
Allen, Gabrielle D., Berriman, Bruce, Choi, Sou-Cheng T., Elster, Anne C., Hanwell, Marcus D., Hetherington, James, Howison, James, Katz, Daniel S., Lapp, Hilmar, Löffler, Frank, Maheshwari, Ketan, Swenson, Shel, Turk, Matthew, Venters, Colin, Wilkins-Diehr, Nancy   +14 more
core   +3 more sources

Sustained Software for Cyberinfrastructure [PDF]

Proceedings of the 1st Workshop on The Science of Cyberinfrastructure: Research, Experience, Applications and Models, 2015
Reliable software that provides needed functionality is clearly essential for an effective distributed cyberinfrastructure (CI) that supports comprehensive, balanced, and flexible distributed CI. Effective distributed cyberinfrastructure, in turn, supports science and engineering applications.
Craig A. Stewart, William K. Barnett, Eric A. Wernert, Julie A. Wernert, Von Welch, Richard Knepper   +5 more
openaire   +1 more source