Results 91 to 100 of about 8,038,703 (314)

Continuous Learning for Automated Early-Stage Alzheimer’s Detection Using MRI and Spike Neural Signals

Advances in Human-Computer Interaction
Alzheimer’s disease (AD), a progressive neurodegenerative disorder whose symptoms become apparent late in the disease process but are only in the early stages of development, creates challenges that demand that this disorder be diagnosed early to reduce ...
Salar Jamal Abdulhameed Al-Atroshi, Rana Layth Abdulazeez, Shadan Mohammed Jihad, Shahab Wahhab Kareem   +3 more
doaj   +1 more source

Using process mapping software to redesign a management system [PDF]

, 2017
Management Systems are becoming de rigueur for Organisations, but many with existing Management Systems are finding that they are creaking at the seams. Changes to Standards, Regulations, Business Practices, Organisation structures and Products mean that
Turner , Sue
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Administration Interface in an e-Testing Software Platform [PDF]

Database Systems Journal, 2011
Administration interfaces represent a subject that requires an in-depth analysis. Due to the complex tasks it needs to execute, the developer of such interfaces must find a perfect balance between aesthetics, functionality, ergonomics and modularity of ...
Diana BUTUCEA
doaj  

Integrating automated support for a software management cycle into the TAME system [PDF]

, 1989
Software managers are interested in the quantitative management of software quality, cost and progress. An integrated software management methodology, which can be applied throughout the software life cycle for any number purposes, is required. The TAME (
Basili, Victor R., Sunazuka, Toshihiko
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Knowledge-based reusable software synthesis system [PDF]

The Eli system, a knowledge-based reusable software synthesis system, is being developed for NASA Langley under a Phase 2 SBIR contract. Named after Eli Whitney, the inventor of interchangeable parts, Eli assists engineers of large-scale software systems
Donaldson, Cammie
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Identifying subtype-specific associations between gene expression and DNA methylation profiles in breast cancer

BMC Medical Genomics, 2017
Background Breast cancer is a complex disease in which different genomic patterns exists depending on different subtypes. Recent researches present that multiple subtypes of breast cancer occur at different rates, and play a crucial role in planning ...
Garam Lee, Lisa Bang, So Yeon Kim, Dokyoon Kim, Kyung-Ah Sohn   +4 more
doaj   +1 more source