Results 151 to 160 of about 31,509,895 (367)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Implementation of Diagnostic Methods of Career Guidance in Computer Systems
Открытое образование (Москва)The purpose of the study is to analyze existing methods and systems of career guidance, evaluate their advantages and disadvantages, and propose our own solution to this problem, taking into account existing developments in this subject area.
Anna P. Sergushicheva
doaj +1 more source
Design of Proposed Software System for Prediction of Iliosacral Screw Placement for Iliosacral Joint Injuries Based on X-ray and CT Images. [PDF]
J Clin Med, 2023 Benda V +5 more
europepmc +1 more source
NASA software specification and evaluation system design [PDF]
The Software Specification and Evaluation System (SSES) manager's guide is presented along with the NSSC-2 computer brochure.
core +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
Assessing the validity of inertial measurement units for shoulder kinematics using a commercial sensor-software system: A validation study. [PDF]
Health Sci Rep, 2022 Henschke J +3 more
europepmc +1 more source
, 1980 © 1980 California Institute of Technology. I wish to thank Dr. Frederick B. Thompson for his patient guidance and help during my graduate studies at Caltech.
openaire +2 more sources
A computer-terminal, hardware/software system with enhanced user input capabilities [PDF]
, 1976 Roy Kaplow, Michael Molnar
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source