Results 71 to 80 of about 31,509,895 (367)

The Oracle Problem in Software Testing: A Survey

IEEE Transactions on Software Engineering, 2015
Testing involves examining the behaviour of a system in order to discover potential faults. Given an input for a system, the challenge of distinguishing the corresponding desired, correct behaviour from potentially incorrect behavior is called the “test ...
Earl T. Barr, M. Harman, Phil McMinn, Muzammil Shahbaz, S. Yoo   +4 more
semanticscholar   +1 more source

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Characterizing the Architectural Erosion Metrics: A Systematic Mapping Study

IEEE Access, 2022
Software architecture is crucial in determining success or failure in a variety of software development and design fields. Typically, as a system evolves, software architecture deteriorates. This phenomenon is known as architectural erosion.
Ahmed Baabad, Hazura Binti Zulzalil, Sa'adah Hassan, Salmi Binti Baharom   +3 more
doaj   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Certifying Controls and Systems Software [PDF]

AIAA Guidance, Navigation and Control Conference and Exhibit, 2007
12 pages, 2 figures, 1 Matlab Code. To be submitted to AIAA journal of guidance and control. In this revised version, support and funding resources were added to the acknowledgement section.
Mardavij Roozbehani, Eric Feron
openaire   +3 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Engineering the software of robotic systems

2017 IEEE/ACM 39th International Conference on Software Engineering Companion (ICSE-C), 2017
The production of software for robotic systems is often case-specific, without fully following established engineering approaches. Systematic approaches, methods, models, and tools are pivotal for the creation of robotic systems for real-world applications and turn-key solutions.
CICCOZZI, FEDERICO, Di Ruscio, Davide, Malavolta, Ivano, Pelliccione, Patrizio, Tumova, Jana   +4 more
openaire   +4 more sources

Serial amplification of tau filaments using Alzheimer's brain homogenates and C322A or C322S recombinant tau

FEBS Letters, EarlyView.
We investigated the seeded assembly of 0N3R tau and two variants, C322A and C322S, designed to model the mutation landscape at residue 322, using Alzheimer's disease brain homogenates in a real‐time quaking‐induced conversion (RT‐QuIC) assay. The C322A variant formed filaments that partially resembled the paired helical filament (PHF) structure ...
Alessia Santambrogio, Sofia Lövestam, Michael A. Metrick II, Thomas Löhr, Peifeng Xu, Nicholas C. T. Gallagher, Bernardino Ghetti, Byron Caughey, Sjors H. W. Scheres, Michele Vendruscolo   +9 more
wiley   +1 more source

Carrying out entrance control of “Informatics” students’ knowledge with use of specialized computer system

Открытое образование (Москва), 2017
Nowadays the creation and the use of computer testing systems is one of perspective directions in the field of control of knowledge. Computer testing makes it possible to: • minimize time expenses at poll and processing of results and their transfer to a
L. V. Larina
doaj   +1 more source