Results 81 to 90 of about 31,509,895 (367)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Russian Open Medical Journal, 2019 Aim ― development of a hardware-software system allowing to treat infected superficial wounds in a liquid environment, designed to provide continuous flow of various irrigation solutions (depending on the wound healing stage) under airtight and water ...
Alexandr A. Basov +4 more
doaj +1 more source
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
Advances in Human-Computer InteractionAlzheimer’s disease (AD), a progressive neurodegenerative disorder whose symptoms become apparent late in the disease process but are only in the early stages of development, creates challenges that demand that this disorder be diagnosed early to reduce ...
Salar Jamal Abdulhameed Al-Atroshi +3 more
doaj +1 more source
Dynamic neural network model for environmental monitoring of vehicle pollution in urban streets [PDF]
FME TransactionsThe gas pollution of the air by vehicle emissions in a sustainable, smart city is an undeniable and urgent problem that requires new methods of solution.
Shepelev Vladimir +3 more
doaj +1 more source
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Business scenarios for interaction in the development of the software system in a start-up software company [PDF]
Икономика и компютърни науки, 2020 The purpose of the article is to consider the issues related to one of the main points in the development of software systems for creating interaction scenarios.
Svetoslav Ivanov, Pavel Petrov
doaj
Hybrid Obfuscation Technique to Protect Source Code From Prohibited Software Reverse Engineering
IEEE Access, 2020 In this research, a new Hybrid Obfuscation Technique was proposed to prevent prohibited Reverse Engineering. The proposed hybrid technique contains three approaches; first approach is string encryption.
Asma'a Mahfoud Hezam Al-Hakimi +4 more
doaj +1 more source
Software itself is not hazardous, but since software and hardware share common interfaces there is an opportunity for software to create hazards. Further, these software systems are complex, and proven methods for the design, analysis, and measurement of
Uber, James G.
core +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source