Results 111 to 120 of about 3,405,045 (356)

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Selenium-Based Multithreading Functional Testing

IJCCS (Indonesian Journal of Computing and Cybernetics Systems), 2018
In a software development projects, testing is an activity that can spend time, effort or cost up to 35%. To reduce this, developers can choose automatic testing.
Khabib Mustofa, Sunu Pinasthika Fajar
doaj   +1 more source

Accelerating covering array generation by combinatorial join for industry scale software testing. [PDF]

PeerJ Comput Sci, 2022
Ukai H, Qu X, Washizaki H, Fukazawa Y.
europepmc   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Systems Development Life Cycle Test Driven Technique and Defect investigation

University of Sindh Journal of Information and Communication Technology, 2019
Software testing is essential to build and improve programming. Software testing is the basic order of construction software. Testing is undoubtedly expensive and involves the biggest individual time.
Soobia Saeed, Asadullah Shaikh, Muhammad Ali Memon, Muhammad Ali Nizamani   +3 more
doaj  

Testing large software with automated software evaluation systems [PDF]

, 1975
C. V. Ramamoorthy, S. F. Ho
openalex   +1 more source

Testing Research Software: An In-Depth Survey of Practices, Methods, and Tools [PDF]

arXiv
Context: Research software is essential for developing advanced tools and models to solve complex research problems and drive innovation across domains. Therefore, it is essential to ensure its correctness. Software testing plays a vital role in this task.
arxiv  

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, EarlyView.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Morphy: A Datamorphic Software Test Automation Tool [PDF]

arXiv, 2019
This paper presents an automated tool called Morphy for datamorphic testing. It classifies software test artefacts into test entities and test morphisms, which are mappings on testing entities. In addition to datamorphisms, metamorphisms and seed test case makers, Morphy also employs a set of other test morphisms including test case metrics and filters,
arxiv