Results 211 to 220 of about 3,646,013 (290)

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

GARDE-Chat: a scalable, open-source platform for building and deploying health chatbots. [PDF]

J Am Med Inform Assoc
Del Fiol G, Borsato E, Bradshaw RL, Bian J, Woodbury A, Gauchel C, Eilbeck KL, Maxwell W, Ellis K, Madeo AC, Schlechter C, Kukhareva PV, Allen CG, Kean M, Elkin EB, Sharaf R, Ahsan MD, Frey M, Davis-Rivera L, Kohlmann WK, Wetter DW, Kaphingst KA, Kawamoto K.   +22 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Using mass spectrometry for robust identity release testing in a global quality control network. [PDF]

MAbs
Leibe S, Violini S, Vollrath M, Bathke A, Nguyen H, Yu H, Harris J, Yu C, Stracke JO, Pallat H, Bell C, Johnson EJ, Stella C, Bulau P.   +13 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

A methodological framework for validating a multi-domain physiological sensor for divers using a scalable data fusion platform. [PDF]

Front Physiol
Beatty P, Tumperi M, Nguyen H, Howe D, Hage P, Wilson R, Lindsey B, Kandel J, Collar B, Gravelyn S, Fulmer G, Sethuraman K, Veith A.   +12 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Translating behavioral interventions into virtual reality: the <i>Transcend Framework</i> for immersive health design. [PDF]

Front Digit Health
Hernandez R, Solai K, Kwon S, Venkatesan P, Fast D, Lara-Cinisomo S, Nisar HJ.   +6 more
europepmc   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source