Results 71 to 80 of about 701,784 (261)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
RUDN Journal of Engineering Research, 2015 An automated system for measuring the diffraction efficiency of light, as well its kinematic scheme, were designed and assembled. The measurements of the diffraction efficiency of light on the sample of polymeric substrates with periodic microrelief were
V V Belyaev +9 more
doaj
2025 IEEE/ACM 47th International Conference on Software Engineering: Software Engineering in Society (ICSE-SEIS)The discipline of software engineering (SE) combines social and technological dimensions. It is an interdisciplinary research field. However, interdisciplinary research submitted to software engineering venues may not receive the same level of recognition as more traditional or technical topics such as software testing.
Sonja M. Hyrynsalmi +3 more
openaire +3 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
International Journal of Information Systems and Project Management, 2022 The concept of Information Systems urbanization has been proposed since the late 1990’s in order to help organizations building agile information systems. Nevertheless, despite the advantages of this concept, it remains too descriptive and presents many
Sana Bent Aboulkacem Guetat +1 more
doaj
Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells
FEBS Letters, EarlyView.DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park +8 more
wiley +1 more source
NeoCoMM: Neocortical neuro-inspired computational model for realistic microscale simulations
SoftwareXThe ability to simulate a neocortical neural network activity at the cellular level is of great interest in many studies. It allows for the investigation of microscopic mechanisms in both healthy and pathological brains.
Mariam Al Harrach +2 more
doaj +1 more source
International Journal of Information Systems and Project Management, 2013 The concept of Information Systems urbanization has been proposed since the late 1990’s in order to help organizations building agile information systems.
Sana Guetat, Salem Dakhli, , ,
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source