Results 101 to 110 of about 3,905,930 (301)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

PROTOTYPE DRAMATIC STAGE LIGHTING CONTROL WITH BLUETOOTH HANDPHONE BASED MICROCONTROLLER ATmega 16 [PDF]

open access: yes, 2012
The final project aims to create a dramatic stage lighting control devices with Bluetooth media are more efficient than current lighting control equipment.
Rinestu, Adhi
core  

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

Development of a tool-kit for the detection of healthy and injured cardiac tissue based on MR imaging

open access: yesCurrent Directions in Biomedical Engineering, 2017
Planning of interventions to treat cardiac arrhythmia requires a 3D patient specific model of the heart. Currently available commercial or free software dedicated to this task have important limitations for routinely use.
Westphal Philip   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A Risk Assessment Method for Narrow Spaces with Low Height

open access: yesApplied Sciences
Work performed in confined and low-height spaces (NSLH) is relatively common across several industries, yet it has not been adequately addressed from an ergonomic perspective. Such activities require workers to adopt awkward postures, most often with the
Adrian Ispășoiu   +4 more
doaj   +1 more source

Business Communication: Director’s Reports [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2019
This paper is based on the scientific literature related to communication issues, especially those concerning companies, with an emphasis on written communication and on how Director’s Reports are organized (in terms of form and content). A software tool
Lavinia Nădrag
doaj  

Developing Educational Software: a professional tool perspective [PDF]

open access: yes, 2000
The selection, and use of educational software and its impact in schools are still controversial issues. In this paper we present an alternative conceptualisation of educational software based on considering the software as an instrument for teachers ...
Hinostroza, Juan Enrique   +3 more
core   +1 more source

Lessons Learned from Development of a Software Tool to Support Academic Advising

open access: yes, 2014
We detail some lessons learned while designing and testing a decision-theoretic advising support tool for undergraduates at a large state university.
Dodson, Thomas   +4 more
core   +1 more source

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