Results 101 to 110 of about 3,928,828 (299)

What Is the Best Way For Developers to Learn New Software Tools? An Empirical Comparison Between a Text and a Video Tutorial

, 2017
The better developers can learn software tools, the faster they can start using them and the more efficiently they can later work with them. Tutorials are supposed to help here.
Kulesz, Daniel, Käfer, Verena, Wagner, Stefan   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A document-like software visualization method for effective cognition of c-based software systems [PDF]

, 2004
It is clear that maintenance is a crucial and very costly process in a software life cycle. Nowadays there are a lot of software systems particularly legacy systems that are always maintained from time to time as new requirements arise.
Sulaiman, Shahida
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Development of a tool-kit for the detection of healthy and injured cardiac tissue based on MR imaging

Current Directions in Biomedical Engineering, 2017
Planning of interventions to treat cardiac arrhythmia requires a 3D patient specific model of the heart. Currently available commercial or free software dedicated to this task have important limitations for routinely use.
Westphal Philip, Hilbert Sebastian, Unger Michael, Chalopin Claire   +3 more
doaj   +1 more source

COSTMODL: An automated software development cost estimation tool [PDF]

The cost of developing computer software continues to consume an increasing portion of many organizations' total budgets, both in the public and private sector.
Roush, George B.
core   +1 more source

Using fast and accurate simulation to explore hardware/software trade-offs in the multi-core era [PDF]

, 2011
Writing well-performing parallel programs is challenging in the multi-core processor era. In addition to achieving good per-thread performance, which in itself is a balancing act between instruction-level parallelism, pipeline effects and good memory ...
Carlson, Trevor, Eeckhout, Lieven, Ghysels, Pieter, Heirman, Wim, Sarkar, Souradip, Vanroose, Wim   +5 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

A Risk Assessment Method for Narrow Spaces with Low Height

Applied Sciences
Work performed in confined and low-height spaces (NSLH) is relatively common across several industries, yet it has not been adequately addressed from an ergonomic perspective. Such activities require workers to adopt awkward postures, most often with the
Adrian Ispășoiu, Ioan Milosan, Camelia Gabor, Mariela Pavalache-Ilie, Gheorghe Oancea   +4 more
doaj   +1 more source