Results 121 to 130 of about 76,454 (276)

A incidência tributária sobre os softwares [PDF]

open access: yes, 2010
No presente trabalho faremos uma análise crítica sob o fenômeno da incidência tributária, com especial ênfase na regra-matriz de incidência tributária, e na teoria do professor Paulo de Barros Carvalho.
Bastos, Rodrigo Garcia
core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

open access: yesMolecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both   +7 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

A Study of compatibility between Iranian digital libraries user interface and the elements of Ellis model of information seeking behavior

open access: yesIranian Journal of Information Processing & Management, 2014
The goal of this study is to evaluate the compatibility between Iranian digital libraries user interface and the elements of Ellis model of information seeking behavior. This study was performed using evaluation method with a checklist.
Yaghoub Norouzi, Naemeh Sokhanvari
doaj  

Review of Softwares Used in Construction Industry

open access: yes, 2016
The use of software and information technology in every field has been growing since last two decades. Earlier softwares were used to be effective in designing field only, later on integration of different modules of business made industries to focus on ...
GHADGE, P. (PRASHANT)
core  

Análise do uso de softwares de simulação termoenergéticas em edificações

open access: yes, 2020
ArtigoAs simulações são saídas ainda pouco utilizadas para previsões de situações ocasionadas na construção civil. Realizou-se um estudo bibliográfico sobre a utilização de softwares de simulação termoenergéticas, a fim de quantificar o conforto ...
Medeiros, Maria Mariana Xavier de Lima
core  

Uma arquitetura de referência para softwares assistentes pessoais baseada na arquitetura orientada a serviços [PDF]

open access: yes, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Automação e SistemasO conceito de softwares assistentes pessoais se firma na ideia de programas de computador que funcionam tal como
Zambiasi, Saulo Popov
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso   +5 more
wiley   +1 more source

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