Results 111 to 120 of about 119,034 (262)

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Thermoelectric Gating Organic Electrochemical Transistors Enabled by Printable Ionogels With n‐p Convertible Thermopower

Advanced Science, EarlyView.
A type of thermoelectric ionogels with convertible n‐p thermopowers are demonstrated with Seebeck coefficients ranging from ‐3.61 to +9.74 mV K−1. Thus, thermoelectric gating organic electrochemical transistor is achieved by employing ionogel as thermoelectric modules and ionic dielectrics simultaneously, paving the road to self‐powered, highly ...
Xingyu Hu, Xinwen Yan, Ling Huang, Xiaohang Zhang, Xuan Cao, Cong Zhang, Qingqing Sun, Hanyu Jia, Xuying Liu   +8 more
wiley   +1 more source

First-in-human (phase I) trial of SOL-116, a humanised IgG4 monoclonal antibody targeting bile salt-stimulated lipase, in healthy participants and rheumatoid arthritis patients. [PDF]

RMD Open
Meijs AC, Kolmert J, Lindquist S, Hovstadius P, Grievink HW, Hällgren A, Wennerholm A, Klarenbeek NB, Hernell O.   +8 more
europepmc   +1 more source

Lunar‐Based Photothermal CO2 Reduction Strategy: Self‐Evolving Transient Active Interface and Band Engineering

Advanced Science, EarlyView.
A self‐evolving Pd/Ov‐FeTiO3 photothermal catalyst, inspired by lunar soil, enables efficient extraterrestrial CO2 conversion. The formation of transient active interfaces and oxygen vacancies extends light absorption to the infrared range and optimizes electron transfer.
Yahang Wang, Yuhuan Li, Quanxin Wang, Deng Li, Pakkin Leong, Meng Wang, Shi Feng, Runyang Mo, Xianjin Shi, Xiaohui Li, Gangqiang Zhu, Chipui Tang   +11 more
wiley   +1 more source

Solasodine, a Natural Steroidal Alkaloid, Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption: A Study Based on Network Pharmacology and Experimental Validation. [PDF]

J Cell Mol Med
Jiang Y, Jin Z, Ji X, Wang M, Cao Z.
europepmc   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source

Self‐Assembly Ordered Layered Gels for Thermochromic Smart Windows With Excellent Electromagnetic Shielding Properties

Advanced Science, EarlyView.
Metal‐ion‐coupled self‐assembled layered gels were prepared using a simple sol–gel method, successfully integrating electromagnetic shielding and thermochromic functions into the material. SCa‐1, which exhibits the best overall performance, achieves an electromagnetic shielding efficiency of up to 72.49 dB, while maintaining a visible light ...
Shusheng Wang, Zijing Li, Shengchong Hui, Hongjing Wu, Shanshan Liang, Fusong Yuan, Limin Zhang   +6 more
wiley   +1 more source

Percutaneous coronary intervention using a mechanical circulatory support system with an Impella centrifugal pump device combined with subsequent cryoablation for atrial fibrillation

Cardiology Journal, 2021
Anna Winnicka-Zielińska, Bogdan Musielak, Jan Budzianowski, Jarosław Hiczkiewicz, Paweł Burchardt   +4 more
doaj   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source