Results 171 to 180 of about 12,195,298 (384)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang +16 more
wiley +1 more source
Assessing a Mitochondrial Disease Treatment via a Novel Statistical Technique for Accelerometer Data
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Therapeutic development for mitochondrial diseases, rare genetic disorders with pathogenic defects of oxidative phosphorylation, is hindered by unsatisfactory outcome measures. To address this problem, we provide the first clinical application of a novel, bias‐adjusted outcome measure of acceleration across a range of subjects ...
Ian W. McKeague +8 more
wiley +1 more source
STUDIES ON THE NATURE OF THE RACEMIC MODIFICATIONS OF OPTICALLY ACTIVE COMPOUNDS IN THE SOLID STATE. PART XIV. METHYL, ETHYL, PHENYL, o- & p-TOLYL AND α- & β-NAPHTHYL CAMPHOR-β-SULPHONATES (d- & dl-) [PDF]
, 1958 BAWA KARTAR SINGH, S. RAMAGOPALA SARMA
openalex +1 more source
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco +18 more
wiley +1 more source
STUDIES ON THE NATURE OF THE RACEMIC MODIFICATIONS OF OPTICALLY ACTIVE COMPOUNDS IN SOLID STATE- PART XVI. P-SULPHONAMIDO-, o-, m-, p-METHOXY-, o-, m-, p-ETHOXYPHENYLAMINOCAMPHORS (d-& di-) AND p-SULPHONAMIDO: o-AND p- METHOXYPHENYLAMINOCAMPHORS (d-& dI-) [PDF]
, 1958 BAWA KARTAR SINGH, BHUPEDRA SAHAT SAXENA
openalex +1 more source
Arthritis Care &Research, EarlyView.Objective Social determinants of health (SDoH) can impact outcomes but are not routinely screened for in US outpatient rheumatology clinics. This study determined the feasibility of routine point‐of‐care SDoH screening among patients with systemic lupus erythematosus (SLE) and associated barriers and facilitators at the physician, care team, and ...
S. Sam Lim +11 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Cognitive impairment (CI) is common in patients with systemic lupus erythematosus (SLE). Despite its prevalence, the immune mechanisms are not well understood. We previously reported elevated serum levels of S100A8/A9 and matrix metalloproteinase 9 (MMP‐9) in patients with SLE and CI.
Carolina Muñoz‐Grajales +18 more
wiley +1 more source