Results 81 to 90 of about 2,028,209 (354)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Welding in solid state

, 2008
The importance of the Solid State Processes (SSP) has increased in the last decade due to the industry demands of improved properties of joined/surfaced materials, combined with cost reduction and energy saving.
Iordachescu, Danut, Iordachescu, Mihaela, Ocaña Moreno, José Luis, Scutelnicu, Elena   +3 more
core  

Recent advances in solid-state organic lasers

, 2011
Organic solid-state lasers are reviewed, with a special emphasis on works published during the last decade. Referring originally to dyes in solid-state polymeric matrices, organic lasers also include the rich family of organic semiconductors, paced by ...
Ahmad, Amarasinghe, Anderson, Andrew, Anker, Baktur, Baldo, Baldo, Bao, Barnes, Baumann, Baumann, Beaufils, Berggren, Berggren, Bergman, Bernanose, Bisri, Bulovic, Butov, Capelli, Casalboni, Chandra, Chang, Chen, Christopoulos, Clark, Coles, Costela, Coulson, Dal Negro, Davis, De Leon, De Leon, Del Carro, Deng, Deshpande, Ding, Dou, Duarte, Faloss, Forget, Forget, Fox, Frolov, Frolov, Frolov, Garcia-Moreno, Gartner, Gather, Gather, Gaylord, Giebink, Goossens, Gorrn, Guilhabert, Gwinner, Görrn, Hecht, Heeger, Heliotis, Heliotis, Heliotis, Hide, Holzer, Holzer, Imamoglu, Ishow, Johansson, Jordan, Karnutsch, Kena-Cohen, Klaers, Klinkhammer, Kogelnik, Koschorreck, Kozlov, Kozlov, Kozlov, Kozlov, Kraabel, Kranzelbinder, Kuznetsov, Lattante, Lebental, Lebental, Leclerc, Lehnhardt, Lehnhardt, Lidzey, List, List, Liu, Maiman, Malliaras, Matsushima, Mayer, McGehee, McGehee, McGehee, Meech, Meerheim, Mo, Moliton, Moses, Muccini, Muñoz, Nakanotani, Nakanotani, Namdas, Noginov, Noginov, Osterbacka, Oulton, Persano, Peterson, Pisignano, Pisignano, Pisignano, Pope, Popov, Rabbani-Haghighi, Rabbani-Haghighi, Rabbani-Haghighi, Rabbani-Haghighi, Rabe, Rabe, Raether, Rahn, Ramos-Ortiz, Reufer, Ribierre, Richardson, Riechel, Riechel, Riedl, Rose, Sakata, Samuel, Samuel, Samuel, Schafer, Schafer, Schawlow, Scherf, Schneider, Schneider, Schneider, Schneider, Schneider, Schols, Schols, Schulzgen, Schön, Schütte, Siegman, Siegman, Soffer, Spehr, Stockman, Stockman, Stroisch, Sun, Takenobu, Tanase, Tang, Tang, Tang, Tessler, Tessler, Tessler, Tessler, Tian, Tsiminis, Tsiminis, Tsutsumi, Turnbull, Valeur, Vannahme, Vasdekis, Vasdekis, Virgili, Wallikewitz, Wegmann, Wenger, Xia, Yamamoto, Yang, Yang, Yang, Yap, Yariv, Yariv, Yokoyama, Yoshioka, Yuyama   +195 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Solid state bistable power switch [PDF]

, 1970
Tin and copper provide high current and switching time capabilities for high-current resettable fuses. They show the best performance for trip current and degree of reliability, and have low coefficients of thermal ...
Bartko, J., Shulman, H.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Strategies to Overcome Undesired Physicochemical Changes in Particle Engineering for Inhalation

KONA Powder and Particle Journal
Particle engineering broadly refers to the controlled production of drug particles optimized for size, morphology, and structure. It encompasses both destructive (top-down) and constructive (bottom-up) particle formation processes, of which the most used
Mariana Romero-Gonzalez, Julia Crowther, Mani Ordoubadi, Ashlee D. Brunaugh   +3 more
doaj   +1 more source