Results 51 to 60 of about 631,922 (278)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Anomalous electrocaloric behaviors in (anti)ferroelectrics: a mini-review

Frontiers in Chemistry
Solid-state cooling, represented by the electrocaloric effect (ECE) in (anti)ferroelectric materials, has emerged as an alternative green refrigeration technology by virtue of its high efficiency and miniaturization and is expected to substitute ...
Feng Li, Feng Li, Chunchang Wang, Lei Shan, Lei Shan   +4 more
doaj   +1 more source

Miniature-scale elastocaloric cooling by rubber-based foils

JPhys Energy, 2023
We report on the design and characterization of a demonstrator device for miniature-scale elastocaloric (eC) cooling using a series of natural rubber (NR) foil specimens of 9 × 26.5 mm ^2 lateral size and thicknesses in the range of 290–900 μ m.
Carina Ludwig, Jan Leutner, Oswald Prucker, Jürgen Rühe, Manfred Kohl   +4 more
doaj   +1 more source

Heat pumping with optically driven excitons

, 2010
We present a theoretical study showing that an optically driven excitonic two-level system in a solid state environment acts as a heat pump by means of repeated phonon emission or absorption events.
A. Grodecka, Erik M. Gauger, G. D. Mahan, H. P. Breuer, Joachim Wabnig   +4 more
core   +1 more source

Solid-state Laser Cooling

Since the first proof-of-concept demonstrations of photoluminescence-based optical refrigeration, solid-state laser cooling has developed into a credible competitor to conventional cryogenic technologies. Solid-state laser cooling continues to advance as new materials push cooling limits.
Ding, Yang, Zhang, Shenghao, Albrecht, Alexander R., Feng, Zhaojie, Forberger, Lars, Tanaka, Hiroki, Hehlen, Markus P., Nemova, Galina, Pauzauskie, Peter J., Seletskiy, Denis V., Kuno, Masaru   +10 more
openaire   +2 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Optical refrigeration with coupled quantum wells [PDF]

, 2015
Refrigeration of a solid-state system with light has potential applications for cooling small-scale electronics and photonics. We show theoretically that two coupled semiconductor quantum wells are efficient cooling media for optical refrigeration ...
Daveau, R. S., Lodahl, P., Stobbe, S., Tighineanu, P.   +3 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source