Results 51 to 60 of about 281,686 (341)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Proposing an Accurate and Fast Optical Batch Inspection Method of Mini-/Micro-LEDs

IEEE Journal of the Electron Devices Society
Based on the microscopic hyperspectral imaging technique, an optical batch inspection method has been proposed by the authors to efficiently and precisely obtain the absolute emission spectra of red (R), green (G), and blue (B) Mini-/Micro-light-emitting
Zhen Li, Mei-Cong Huang, Xiong-Jun Cao, Da Xu, Yi Lin, Zhong Chen, Zi-Quan Guo   +6 more
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Optimization on Adhesive Stamp Mass-Transfer of Micro-LEDs With Support Vector Machine Model

IEEE Journal of the Electron Devices Society, 2020
In this work, the process of adhesive stamp mass-transfer of micro light-emitting diode (micro-LED) is optimized by a Support Vector Machine (SVM) model.
Hao Lu, Weijie Guo, Changwen Su, Xilong Li, Yijun Lu, Zhong Chen, Lihong Zhu   +6 more
doaj   +1 more source

Color Point Tuning for (Sr,Ca,Ba) Si2O2N2:Eu2+ for White Light LEDs [PDF]

, 2009
Color point tuning is an important challenge for improving white light LEDs. In this paper, the possibilities of color tuning with the efficient LED phosphor Sr1−x−y−zCaxBaySi2O2N2:Euz2+ (0 ≤ x, y ≤ 1; 0.005 ≤ z ≤ 0.16) are investigated.
Bachmann, Volker, Meijerink, Andries, Oeckler, Oliver, Ronda, Cees, Schnick, Wolfgang   +4 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Assessment and Optimization of the Circadian Performance of Smartphone-Based Virtual Reality Displays

IEEE Journal of the Electron Devices Society, 2019
The non-visual effects of blue light in displays mean that excessive use of smartphones can disturb the human circadian rhythm. Thus, the impact of virtual reality (VR) headsets, which are worn closer to the human eye, may be even more serious.
Tingzhu Wu, Shijie Liang, Lili Zheng, Yue Lin, Ziquan Guo, Yulin Gao, Yijun Lu, Sung-Wen Huang Chen, Chun-Fu Lee, Jia-Rou Zhou, Hao-Chung Kuo, Zhong Chen   +11 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source