Results 21 to 30 of about 29,861 (262)
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Study of solid-state transformer [PDF]
, 2018 Transformers are used to control the network voltages by changing the transformation ratio. The conventional transformers are able to perform very well in regulating the voltages by either stepping up or down voltages within certain limits depending on ...
Choo, Ren You
core
Solid-State Transformer (S2T) of Single Phase Matrix Converter [PDF]
, 2018 Solid-State Transformer (S2T) also known as Power Electronic Transformer (PET) is applied in various industrial fields compared to the conventional transformer due to it flexible voltage transfer ratio, high power density, and low harmonic distortion ...
Baharom, Rahimi +3 more
core +2 more sources
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
, 2018 The Solid State Transformer (SST) is an emerging solution that can advantageously substitute the conventional transformer, thanks to its capabilities. Furthermore, it is a multi-functional equipment that offers: - conditioning of the power flow, whether
Fontana, Christian
core
Hybrid solid state transformer : concept, design and implementation [PDF]
Transformers have been an integral part of the electric grid since the dawn of commercial electrification more than a century ago, stepping up/down the voltage, enabling transmission and distribution of electrical power effectively.
Rajendran, Sanjay
core +1 more source
Mechanochemically Induced Solid-State Transformations of Levofloxacin
Molecular PharmaceuticsLevofloxacin hemihydrate (LVXh) is a complex fluoroquinolone drug that exists in both hydrated and anhydrous/dehydrated forms. Due to the complexity of such a compound, the primary aim of this study was to investigate the amorphization capabilities and solid-state transformations of LVXh when exposed to mechanical treatment using ball milling.
Lena Kadri +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source