Results 41 to 50 of about 703,218 (296)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Anisotropic Elastoplastic Damage Mechanics Method to Predict Fatigue Life of the Structure
Advances in Materials Science and Engineering, 2016 New damage mechanics method is proposed to predict the low-cycle fatigue life of metallic structures under multiaxial loading. The microstructure mechanical model is proposed to simulate anisotropic elastoplastic damage evolution.
Hualiang Wan, Qizhi Wang, Zheng Zhang
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Development of Anisogrid Lattice Composite Structures for Fighter Wing Applications
International Journal of Aerospace EngineeringThis paper presents research on the use of anisogrid lattice structures in fighter wing applications. While the anisogrid lattice structure has been widely used in spacecraft structures, its implementation in main aircraft structures is still limited ...
Muhammad Kusni +3 more
doaj +1 more source
Research on Panel Flutter Considering the Effect of Convective Active Cooling
Applied Sciences, 2023 The aeroelastic characteristics of the panel under the action of coolant are obviously different from the flutter characteristics of the traditional panel.
Jie Huang +3 more
doaj +1 more source
Reduction theory and the Lagrange–Routh equations [PDF]
, 2000 Reduction theory for mechanical systems with symmetry has its roots in the classical works in mechanics of Euler, Jacobi, Lagrange, Hamilton, Routh, Poincaré, and others.
Marsden, Jerrold E. +2 more
core +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Automated Camera Exposure Control for Accuracy-Enhanced Stereo-Digital Image Correlation Measurement
Sensors, 2022 An automated camera exposure control method, which allows a two-camera stereo-digital image correlation (stereo-DIC) system to capture high-quality speckle image pairs, is presented for accuracy-enhanced stereo-DIC measurement.
Xiaoying Zhang +3 more
doaj +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source