Results 131 to 140 of about 4,439,439 (300)
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Numerical Prediction of the Effect of Typical Particle Properties on a Centrifugal Pump
IEEE AccessTo grasp the hydraulic performance and abrasion characteristics of a particular model pump before manufacture, this paper firstly numerically calculates the three-dimensional viscous steady incompressible flow of a solid-liquid two-phase flow centrifugal
Yingyu Ji +5 more
doaj +1 more source
Modeling solid-to-solid biocatalysis
In this thesis, a kinetic model is described for the conversion of solid Ca-maleate to solid Ca-D-malate. The reaction is catalysed by maleate hydratase in permeabilized Pseudomonas pseudoalcaligenes and is executed in a batch reactor seeded with Ca-D-malate (product) crystals.
openaire +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Homogeneous Diffusion Solid Model as a Realistic Approach to Describe Adsorption onto Materials with Different Geometries. [PDF]
Nanoscale Res Lett, 2016 Sabio E +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Comparison and Research on Fatigue Strength Analysiswith Different FE Modeling Methods
机车电传动, 2016 In order to improve the efficiency of engineering structural strength analysis, two types of model that solid element modeland solid-shell element model were created based on ANSYS and HyperMesh software.
QU Wenhui, MI Caiying
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Exploring Gas/Solid Interface Reactions of Solid Oxide Cell Electrodes via Model Thin‐Film Systems
EcoMatSolid oxide cells (SOCs) are promising energy conversion devices capable of efficiently converting electrical energy to chemical energy and vice versa. Enhancing efficiency and durability in SOCs necessitates a thorough understanding of the electrode's ...
Jinwook Kim +4 more
doaj +1 more source