Results 41 to 50 of about 18,613,039 (295)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
South Carolina Solid Waste Management annual report fiscal year 2007 [PDF]
, 2008 DHEC is required to publish an annual report based in part on information that counties and solid waste facilities are required to provide. This report reflects solid waste management activities in fiscal year and includes: the amount of material ...
South Carolina Division of Mining and Solid Waste Management
core +1 more source
The Need for Experimental and Numerical Analyses of Thermal Ageing in Power Transformers
Energies, 2022 Most power transformers are oil-immersed transformers for which its insulation system consists of oil and cellulosic solid. The insulation liquid impregnates the solid-covering air spaces, which improves the efficiency of the insulation system.
Inmaculada Fernández
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Comparison of Isolated DC-DC Converters for Low/Medium Voltage Solid State Transformer applications [PDF]
Journal of Electrical and Electronics Engineering, 2022 This paper presents a comparative evaluation of isolated dc-dc converter topologies used in Solid State Transformers (SST) meant for low/medium voltage standalone applications.
R B Jeyapradha, V Rajini
doaj
Design of Solid State Transformer
International Journal of Advanced Research in Electrical, Electronics and Instrumentation Engineering, 2015 Transformers are designed so as to minimize weight and cost based on three presumptions: the power supply is with a sine wave, the frequency is fixed, and the voltage not to exceed a prescribed maximum limit. Fastidious approach in designing the transformer based on these assumptions is not entailed, then again proper consideration is required if the ...
B. Dheeraj Reddy, Dr. Sarat Kumar Sahoo
openaire +1 more source