Results 41 to 50 of about 9,019 (263)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

4.5 kW High Frequency Transformer Design for Dual Active Bridge (DAB)

Jurnal Elkomika
ABSTRAK Indonesia bertujuan untuk beralih dari bahan bakar fosil ke sumber energi terbarukan, dengan target integrasi sebesar 23% pada tahun 2025 dan 31% pada tahun 2050.
NAUFAL HILMI FAUZAN, EKA FIRMANSYAH, FELIX AUSTIN CAHYADEWA   +2 more
doaj   +1 more source

Design and Implementation of a LLC Resonant Solid State Transformer

IEEE Transactions on Industry Applications, 2020
In this study, analysis and control of a highly efficient, high-power full-bridge unidirectional resonant LLC solid-state transformer (SST) are discussed. A combination of pulse frequency modulation and phase-shift modulation is utilized to control this resonant converter for a wide load range.
Rashidi, Mohammad, Altin, Necmi, Ozdemir, Saban, Bani-Ahmed, Abedalsalam, Sabbah, Mohamad, Balali, Farhad, Nasiri, Adel   +6 more
openaire   +3 more sources

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Copper Pipes as Medium Frequency Transformer Windings

IEEE Access, 2022
Owing to increasing power demand, new technologies, such as solid-state transformers, are progressively researched and improved. Thereby, galvanic isolation and voltage adaptation are achieved by medium frequency transformers. To reach high power density
Nikolina Djekanovic, Drazen Dujic
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Isolation Transformer for 3-Port 3-Phase Dual-Active Bridge Converters in Medium Voltage Level

IEEE Access, 2019
In this paper, an isolation transformer with integrated filter inductances for three-phase three-port dual-active bridge (DAB) converters in the wye-wye-delta (Yyd) configuration is introduced and designed.
Seunghun Baek, Subhashish Bhattacharya
doaj   +1 more source

Comparison of Isolated DC-DC Converters for Low/Medium Voltage Solid State Transformer applications [PDF]

Journal of Electrical and Electronics Engineering, 2022
This paper presents a comparative evaluation of isolated dc-dc converter topologies used in Solid State Transformers (SST) meant for low/medium voltage standalone applications.
R B Jeyapradha, V Rajini
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source