Results 301 to 310 of about 540,096 (367)

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

A Bioinspired Approach to Next-Generation Vaccines in Solid Tumors with Engineered Cell Membranes. [PDF]

Research (Wash D C)
Zhang W, Chen M, Huang X.
europepmc   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Adapter-based allogeneic CAR T cells to overcome antigen escape in solid tumors. [PDF]

Front Immunol
Pham PQ, Sodji QH.
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Efficacy and safety of tocilizumab for neoplastic fever in patients with advanced solid tumors: a multicenter retrospective study. [PDF]

Oncologist
Yan Y, Liu X, Du Y, Dou Q, Wang H, Si X, Zhang X, Wu X, Zhou Y, Li M, Zhong W, Wang M, Zhang L.   +12 more
europepmc   +1 more source

Optimizing next-generation CAR-macrophages against solid tumors: challenges and potential strategies. [PDF]

J Hematol Oncol
Chen Y, Zhou L, Chen X, Wang S, Chen W, Li Z, Qiu J, Li R, Tu J, Lin N.   +9 more
europepmc   +1 more source

CAR-T cells in solid tumors: engineering, biomarkers, translational pathways and the road ahead. [PDF]

Front Immunol
Al Shaer NSH, Masoud I, Tleyjeh A, Al-Attas AA, Al-Attas MA, Khan MI, Yaqinuddin A.   +6 more
europepmc   +1 more source

Obstacles and improvement strategies for CAR-T cell therapy in solid tumors. [PDF]

Discov Oncol
Luo Z, Hu Q, Ren M, Wang L, Zou Q, Wen X, Chen S, Liu Q, Luo D, Guo Z.   +9 more
europepmc   +1 more source

Tumor-microenvironment-modulating microspheres to augment tumor-infiltrating lymphocyte therapy against solid tumors. [PDF]

Cell Rep Med
Li M, Yan S, Yan X, Nie Z, Wang H, Li Q, Liu H, Yu W, Zhang S, Liu Y, Chen H, Wu WD, Chao Y, Liu Z.   +13 more
europepmc   +1 more source