Results 231 to 240 of about 720,989 (310)

Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors. [PDF]

Cancer Res
ElHarouni D, Hernansaiz-Ballesteros R, Peterziel H, Balasubramanian GP, Previti C, Schramm K, Blattner-Johnson M, Kabbe R, Jones BC, Oppermann S, Jones DTW, Pfister SM, Witt O, Saez-Rodriguez J, Oehme I, Jäger N, Schlesner M.   +16 more
europepmc   +1 more source

Bioengineered Pancreatic Cancer Immunosuppressive Microenvironment Models for Screening Immunotherapies

Advanced Healthcare Materials, EarlyView.
Bioengineering tumor‐stroma pancreatic cancer models with potential to emulate the native immunosuppressive tumor microenvironment. Cancer‐on‐a‐bead models exhibited higher relevance for screening immunotherapies and modulating the protumoral PDAC microenvironment. ABSTRACT Pancreatic cancer is notably resistant to treatment, primarily due to its dense
Maria V. Monteiro, Margarida Henriques‐Pereira, Bruno M. Neves, Vítor M. Gaspar, João F. Mano   +4 more
wiley   +1 more source

Impact of geriatric impairments on outcomes of single-agent immunotherapy in solid tumors. [PDF]

Int J Cancer
Özkan A, de Joode K, Kapiteijn E, Slingerland M, Zunder S, van den Bos F, Mooijaart S, Uit den Boogaard A, Trompet S, Westgeest H, van der Veldt A, Mathijssen RHJ, Labots G, Holterhues C, Verdegaal EME, de Glas NA, Portielje JEA.   +16 more
europepmc   +1 more source

Metronidazole‐Loaded Cyclodextrin Nanogels for Antibacterial Therapy and Microbiota Regulation in Periodontitis

Advanced Healthcare Materials, EarlyView.
A methacrylamide β‐cyclodextrin‐based nanogel (MACD nGel) is developed to load the antimicrobial drug Metronidazole (MNZ) for topical delivery for the treatment of periodontitis. It is demonstrated that cyclodextrin nanogel (nGel) loaded with metronidazole provides an efficient drug delivery route but also has potential clinical applications and offers
Yanjing Ji, Ruichen Zhang, Dongyi Xu, Patrick C. A. van der Wel, Alessia Lasorsa, Guotai Li, Fangze Guo, Qihui Zhou, Patrick van Rijn   +8 more
wiley   +1 more source

Impact of MGMT methylation on overall survival in solid tumors: A systematic review and meta-analysis. [PDF]

Exp Ther Med
Alzibdeh A, Khanfar A, Al-Hussaini M, Abuhijlih R, Mohamad I, Abdel-Razeq H, Abuhijla F.   +6 more
europepmc   +1 more source

Compression‐Tension‐Asymmetry and Stiffness Nonlinearity of Collagen‐Matrigel Composite Hydrogels

Advanced Healthcare Materials, EarlyView.
Self‐assembled collagen hydrogel matrices are widely used in tissue engineering applications. These matrices stiffen and contract laterally under tension due to fiber alignment and soften and collapse under compression due to fiber buckling. It is demonstrated that filler materials, such as Matrigel, linearize the mechanical behavior of collagen ...
David Böhringer, Jan Hinrichsen, Radik Gataulin, Sandra Wiedenmann, Marina Spörrer, Selda Sherifova, Paul Steinmann, Gerhard A. Holzapfel, Ben Fabry, Silvia Budday   +9 more
wiley   +1 more source

Outcome of Infantile Malignant Solid Tumors: A Single-Center Experience. [PDF]

Children (Basel)
Tufan Taş B, Eker N.
europepmc   +1 more source

A Human‐Based Skin‐Lymphoreticular Model‐on‐Chip to Emulate Inflammatory Skin Conditions

Advanced Healthcare Materials, EarlyView.
A human‐based lymphoreticular (LR) model was developed through guided self‐assembly and integrated in a skin‐lymphoreticular co‐culture in a microfluidic organ‐on‐chip to mimic interactions between skin and its draining lymph nodes. The human‐based skin‐lymphoreticular model resembles a minimally functional unit that allows to study interactions ...
Zheng Tan, Partho Protim Adhikary, Dana Wörz, Sarah Hedtrich   +3 more
wiley   +1 more source

Evaluation of the Idylla IDH1-2 Mutation Assay for the Detection of IDH Variants in Solid Tumors and Hematological Malignancies. [PDF]

Int J Mol Sci
Gilson P, Muller M, Gauchotte G, Fadil S, Husson M, Hanriot I, Witz A, Dardare J, Betz M, Merlin JL, Harlé A.   +10 more
europepmc   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source