Results 281 to 290 of about 755,181 (358)

Cergutuzumab Amunaleukin in Combination with Atezolizumab in Patients with Carcinoembryonic Antigen-Positive Advanced/Metastatic Solid Tumors. [PDF]

Clin Cancer Res
Melero I, Tabernero J, Steeghs N, Robbrecht DGJ, Peters S, Rizvi NA, O'Reilly EM, Calvo E, Eefsen RL, Leighl N, Cervantes A, Hafez N, Habigt C, Andersson E, Dejardin D, Rossmann E, Martinez Quetglas I, Babitzki G, Duarte J, Adessi C, Boetsch C, Evers S, Charo J, Teichgräber V, Lassen U.   +24 more
europepmc   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

CAR-T cell therapy for pediatric solid tumors: armored CAR-T cells and beyond. [PDF]

Cancer Metastasis Rev
Wells J, Gupta A.
europepmc   +1 more source

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Immune cell-based therapies for solid tumors, current challenges and therapeutic advances. [PDF]

Cell Commun Signal
Torabi S, Yekzaman E, Taherkhani S, Talachi N, Khoshravesh R, Khosravi A, Salehi M, Zarrabi A, Vosough M.   +8 more
europepmc   +1 more source

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

Clonal Hematopoiesis and Cardiovascular Disease Risk After Cancer Therapy in Patients With Solid Tumors.

JAMA Oncol
Shyr D, Pershad Y, Zhao K, Kishtagari A, Corty RW, Shinohara E, Park BH, Heimlich JB, Luo L, Bick AG.   +9 more
europepmc   +1 more source

Plant‐Produced Viral Nanoparticles Decorated with Nanobodies Against HER2 Improve Retention and Recruitment of Immune Cells in Solid Tumors

Advanced Healthcare Materials, EarlyView.
Potato virus X is a filamentous RNA plant virus that can be engineered into a molecular tool for cancer therapy. We produced genetically‐encoded virus‐derived nanoparticles decorated with nanobodies targeting cancer cell receptors, epidermal growth factor receptor (EGFR) and human epidermal growth factor 2 (HER2).
Enrique Lozano‐Sanchez, Miguel A. Moreno‐Gonzalez, Fernando Merwaiss, Nicole F. Steinmetz, José‐Antonio Daròs   +4 more
wiley   +1 more source

A Superhydrophobic 3D Cell Culture System Reveals the Mechanobiological Role of Cancer‐Associated Fibroblasts in Prostate Cancer Metastasis

Advanced Healthcare Materials, EarlyView.
A superhydrophobic 3D cell culture platform enables rapid and consistent formation of heterotypic tumor–stroma clusters, and reveals how physiological shear conditions influence metastatic signaling. Mechanical stimulation of cancer‐associated fibroblasts promotes sustained cytokine secretion and survival‐promoting pathways, showing how multicellular ...
Alexandria T. Carter, Abigail R. Fabiano, Ehsan Aalaei, Jason Deng, Dakota E. Rostant, Michael R. King   +5 more
wiley   +1 more source

The impact of immune checkpoint inhibitors on gonadal function in patients with solid tumors. [PDF]

ESMO Open
van Dijk B, de Joode K, Louwers YV, Verheul HMW, Mathijssen RHJ, Chaker L, van der Wal R, van den Berg SAA, Dinkelman-Smit M, Visser JA, van der Veldt AAM.   +10 more
europepmc   +1 more source