Results 91 to 100 of about 2,076,289 (344)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Tumor growth instability and the onset of invasion

, 2005
Motivated by experimental observations, we develop a mathematical model of chemotactically directed tumor growth. We present an analytical study of the model as well as a numerical one.
A. H. Nayfeh, A. J. Ekstrand, A. J. Ekstrand, A. Wells, A.-L. Barabási, Carmen Molina-París, D. S. Jones, H. M. Byrne, J. A. Sherratt, J. P. Freyer, J. P. Freyer, M. J. Holmes, M. R. Chicoine, M. R. Chicoine, Mario Castro, P. C. Fife, P. Grindrod, R. K. Jain, S. H. Strogatz, S. Koochekpour, Thomas S. Deisboeck   +20 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Solute trapping and non-equilibrium microstructure during rapid solidification of additive manufacturing. [PDF]

Nat Commun, 2023
Ren N, Li J, Zhang R, Panwisawas C, Xia M, Dong H, Li J.   +6 more
europepmc   +1 more source

Effect of Elementally Blended Ni-Ti and Pre-Alloyed Nitinol Powders on Solidification Behaviour During Laser Bed Powder Fusion (L-Pbf)

, 2023
Declan Bourke, Karthikeyan Tamilselvam, Muhannad Ahmed Obeidi, Inam Ul Ahad, Dermot Brabazon   +4 more
openalex   +1 more source

Bulk Glass Formation in Eutectic of La-Cu-Ni-Al Metallic Alloys [PDF]

, 2003
A eutectic in La-rich La-Cu₀.₅Ni₀.₅-Al alloys was determined by studying the melting behaviors and the microstructure observations.
Li, Yi, Tan, Hao, Zhang, Yong
core  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Solidification behaviour of ceramic particle reinforced Al-alloy matrices

Journal of Materials Science, 2009
Novel metal matrix composites have been produced by cast production route. TiC and WC ceramic reinforcing particles have been successfully introduced into Al 6060, Al 319, Al 356, Al–7Si–5Mg, Al–20Cu and Al 2007 alloys. Refined grain structure and various intermetallic phase formation have been observed.
Karantzalis, A. E., Lekatou, A., Georgatis, E., Mavros, H.   +3 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source