Results 101 to 110 of about 2,076,289 (344)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Modelling and simulations of ductile iron solidification- induced variations in mechanical behaviour on component and microstructural level [PDF]

, 2015
Jakob Olofsson, Kent Salomonsson, Ingemar Svensson   +2 more
openalex   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

The effect of phosphorus on solidification behaviour of undercooled Al–70 wt.%Si alloys [PDF]

, 2020
Bo Dang, Zengyun Jian, Junfeng Xu
openalex   +1 more source

Solidification behaviour of magnesium alloys

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University. Magnesium alloys have been extensively used for structural and functional applications due to their low densities. In order to improve the mechanical properties, grain refinement of the microstructures of magnesium alloys has been studied for many years ...
openaire   +1 more source

AlMg5 Alloy Behaviour under Different Solidification Conditions

RECENT - REzultatele CErcetărilor Noastre Tehnice
Various solidification conditions of processing alloys have a strong influence on microstructure development, often leading to extended solid-state solubility. In this study, the solubility of Mg in the α-Al solid solution was investigated by varying the solidification conditions of the AlMg5 alloy.
openaire   +1 more source

Effect of Temperature Gradient and Cooling Rate on the Solidification of Iron: A Molecular Dynamics Study

Materials
In this study, molecular dynamics (MD) simulations were employed to compare the effects of different solidification conditions on the solidification behaviour, stress distribution, and degree of crystallization of iron.
Qin Qin, Weizhuang Li, Wenrui Wang, Dongyue Li, Lu Xie   +4 more
semanticscholar   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Solidification behaviour of Al–Si based alloys with controlled additions of Eu and P [PDF]

, 2018
Jiehua Li, Thomas H. Ludwig, Bernd Oberdorfer, Peter Schumacher   +3 more
openalex   +1 more source