Results 51 to 60 of about 2,059,621 (303)

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

open access: yesMolecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla   +5 more
wiley   +1 more source

Numerical analysis of molten iron flow and heat transfer in plumbing casting defect detection using split tracking approach

open access: yesCase Studies in Thermal Engineering
Gravity sand casting, widely utilised in plumbing manufacturing for metal part production, is the focus of this research to enhance its efficiency.
Sirawit Namchanthra   +7 more
doaj   +1 more source

Thermal analysis as a microstructure prediction tool for A356 aluminium parts solidified under various cooling conditions [PDF]

open access: yes, 2011
Thermal analysis technique has been used for a long time, in both ferrous and nonferrous industries for evaluating the metallurgical quality of the liquid metal before casting.
Abaunza, Unai   +4 more
core  

Front propagation in a phase field model with phase-dependent heat absorption [PDF]

open access: yes, 2013
Copyright © 2006 Elsevier. NOTICE: This is the author’s version of a work accepted for publication by Elsevier. Changes resulting from the publishing process, including peer review, editing, corrections, structural formatting and other quality control ...
Alexander   +38 more
core   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner   +6 more
wiley   +1 more source

Microstructure Control and Performance Evolution of Aluminum Alloy 7075 by Nano-Treating. [PDF]

open access: yes, 2019
Nano-treating is a novel concept wherein a low percentage of nanoparticles is used for microstructural control and property tuning in metals and alloys. The nano-treating of AA7075 was investigated to control its microstructure and improve its structural
Cao, Chezheng   +5 more
core  

Experimental investigation of the influence of the FSW plunge processing parameters on the maximum generated force and torque [PDF]

open access: yes, 2010
The paper presents the results of an experimental investigation, done on the friction stir welding (FSW) plunging stage. Previous research works showed that the axial force and torque generated during this stage were characteristic for a static ...
BIGOT, Régis   +3 more
core   +3 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

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