Results 91 to 100 of about 116,969 (285)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effects of Chemical Composition and Solidification Rate on the Solidification Behavior of High-Cr White Irons

Metals
The effects of chemical composition and solidification rate on the solidification behavior of high-Cr white irons were investigated through directional solidification.
Hee Young Son, In Yong Jung, Baig Gyu Choi, Jong Ho Shin, Chang Yong Jo, Je Hyun Lee   +5 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A Feature of the Horizontal Directional Solidification (HDS) Method Affects the Microstructure of Al₂O₃/YAG Eutectic Ceramics

Crystals
The solidification processes of two compositions, hypereutectic (21.0 mol% Y2O3–79.0 mol% Al2O3) and eutectic (18.5 mol% Y2O3–81.5 mol% Al2O3), were used via the horizontal directional solidification (HDS) method to produce two ingots with dimensions of ...
Juraj Kajan, Grigori Damazyan, Vira Tinkova, Anna Prnová, Monika Michálková, Peter Švančárek, Tomáš Gregor, Alena Akusevich, Branislav Hruška, Dušan Galusek   +9 more
doaj   +1 more source

Effect of casting technology on microstructure and phases of high carbon high speed steel [PDF]

China Foundry, 2011
The as-cast microstructures of high carbon high speed steels (HC-HSS) made by sand casting, centrifugal casting and electromagnetic centrifugal casting, respectively, were studied by using of optical microscopy (OM) and D/max2200pc X-ray diffraction. The
Zhang Tianming, Wang Qinjuan, Song Xuding   +2 more
doaj  

Influences of Alternating Magnetic Fieldson the Growth Behavior and Distribution of the Primary Fe Phasein Cu-14Fe Alloys during the Solidification Process

Metals, 2018
An alternating magnetic field (AMF) was applied during the solidification process of the Cu-14Fe alloy and the effect of the electromagnetic parameter, which impact the model and solidification technique of the solidification structure that were analyzed.
Jin Zou, De-Ping Lu, Ke-Ming Liu, Qing-Feng Fu, Zhe Zhou   +4 more
doaj   +1 more source

Method of growing composites of the type exhibiting the Soret effect [PDF]

, 1977
A predetermine amount of segregation is introduced into a molten sample of a composite that exhibits the Soret effect, such amount approximating the amount of segregation resulting from directional solidification of the sample.
Bhat, B. N.
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Optimisation of Solidification Structure and Properties of Hypoeutectic Chromium Cast Iron. [PDF]

Materials (Basel), 2022
Siekaniec D, Kopyciński D, Tyrała E, Guzik E, Szczęsny A.   +4 more
europepmc   +1 more source