Results 81 to 90 of about 116,969 (285)

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Phase-field-crystal models for condensed matter dynamics on atomic length and diffusive time scales: an overview [PDF]

open access: yes, 2012
Here, we review the basic concepts and applications of the phase-field-crystal (PFC) method, which is one of the latest simulation methodologies in materials science for problems, where atomic- and microscales are tightly coupled. The PFC method operates
Artemev A.   +31 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Investigation on the Solidification Structure of Q355 in 475 mm Extra-Thick Slabs Adopting Cellular Automaton-Finite Element Model

open access: yesMetals
The solidification structure characteristics are decisive for the production of extra-thick slabs. This study developed a solidification heat transfer model and a cellular automaton–finite element coupled model to investigate the solidification behavior ...
Kezai Yu   +5 more
doaj   +1 more source

Adaptive Mesh Refinement Computation of Solidification Microstructures using Dynamic Data Structures

open access: yes, 1998
We study the evolution of solidification microstructures using a phase-field model computed on an adaptive, finite element grid. We discuss the details of our algorithm and show that it greatly reduces the computational cost of solving the phase-field ...
Almgren   +44 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Comparison of Transverse Uniform and Non-Uniform Secondary Cooling Strategies on Heat Transfer and Solidification Structure of Continuous-Casting Billet

open access: yesMetals, 2019
Water flux distribution largely influences the heat transfer and solidification of continuously-cast steel billets. In this paper, a secondary cooling strategy of transverse non-uniform water flux (i.e., higher flux density on billet center), was ...
Yanshen Han   +6 more
doaj   +1 more source

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