Results 61 to 70 of about 134,981 (262)

Young interior designers’ creative pattern to draw potential consumers’ attention: Expectation, capital, and strategy

Journal of Graphic Engineering and Design
One of the initial problems faced by young interior designers is to make a creative pattern to draw potential consumers’ attention. Their belief in the creative pattern should fit consumers’ expectations.
Florista F. Marimba, Ahmad Faizin, Andreas S. Widodo, Lulu Purwaningrum   +3 more
doaj   +1 more source

Potássio, cálcio e magnésio na micropropagação de plantas tropicais ornamentais

Ornamental Horticulture, 2016
Considerando a crescente importância econômica de espécies da família Zingiberaceae para a floricultura e as vantagens das técnicas aplicadas ao cultivo in vitro para estas plantas, torna-se necessária a realização de estudos que avaliem o crescimento ...
Viviane Amaral Toledo Coelho, Gabrielen de Maria Gomes Dias, Cleber Lázaro Rodas, Moacir Pasqual, Mozart Martins Ferreira, Maria Ligia de Souza Silva   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

ANALISIS FAKTOR - FAKTOR YANG MEMPENGARUHI KETERSEDIAAN OBAT DI ERA JKN PADA RUMAH SAKIT UMUM DAERAH

Jurnal Manajemen dan Pelayanan Farmasi, 2016
Ketersediaan obat sangat penting berhubungan erat dengan mutu pelayanan. Ketrersediaan obat merupakan pilar utama dalam menciptakan kepuasan pasien, dokter, tenaga kefarmasian.
Pulung Prabowo, Satibi Satibi, Gunawan Pamudji   +2 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Maximum discharge and probable rainfall at Aiuruoca basin, Minas Gerais State

Revista Ambiente & Água, 2014
Research on rainfall and annual daily maximum discharge rates is essential to support decisions during the design of hydraulic structures. This study tested the adequacy of probability functions to predict the probable rainfall and discharge rates of the
Leandro Campos Pinto, Pedro Luiz Terra Lima, Zélio Resende de Souza   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source