Results 91 to 100 of about 78,386 (291)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Exposição didática de solos : roteiro da visita autoguiada
, 2023 "Programa de Extensão Universitária Solo na Escola / UFPR, Projeto de Extensão Universitária Exposição Didática de ...
Tavares, Stéfany Rodrigues
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Estudo do comportamento geomecânico de solos residuais de granito de Florianópolis [PDF]
, 2004 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Civil.O meio físico de Florianópolis apresenta grandes extensões de morros de rochas graníticas com comportamento geotécnico ...
Bevilaqua, Fernanda Ziegler
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Aterros Sobre Solos Moles: Dimensionamento dos Encontros da Ponte Sobre o Rio Três Riachos, BR-101 (SC) [PDF]
, 2015 TCC (graduação) - Universidade Federal de Santa Catarina. Centro Tecnológico. Engenharia Civil.No presente trabalho apresenta-se o estudo dos solos de baixa consistência presentes no solo de fundação da ponte sobre o rio Três Riachos, uma das obras da ...
Santos, Felipe Souza dos
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Environmental Research Letters, 2019 This study aimed to test two hypotheses: (i) on the Brazilian semiarid territory, the climate has greater weight as a driver of vegetation than the soil and; (ii) the arboreal Caatinga is a vegetation whose environmental attributes are similar to the Dry
Guilherme de Castro Oliveira +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Embrapa Solos: relatório anual 2019.
, 2020 Este relatório reúne as principais práticas de gestão e os destaques nas áreas de Pesquisa, Desenvolvimento e Inovação alcançados pela Embrapa Solos no ano de 2019.
EMBRAPA SOLOS.
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