Results 61 to 70 of about 31,450 (207)

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Advection‐Pressure Splitting Schemes Applied to a Non‐Conservative 1D Blood Flow Model With Transport for Arteries and Veins

International Journal for Numerical Methods in Fluids, EarlyView.
We introduce new efficient and accurate first order finite volume‐type numerical schemes, for the non‐conservative one‐dimensional blood flow equations with transport, taking into account different velocity profiles. The framework is the flux‐vector splitting approach of Toro and Vázquez‐Cendón (2012), that splits the system in two subsystems of PDEs ...
Alessandra Spilimbergo, Eleuterio F. Toro, Annunziato Siviglia, Lucas O. Müller   +3 more
wiley   +1 more source

Impact of Uncertain Parameters on Navier–Stokes Equations With Heat Transfer via Polynomial Chaos Expansion

International Journal for Numerical Methods in Fluids, EarlyView.
This study investigates the impact of uncertain parameters on Navier–Stokes equations coupled with heat transfer using the Intrusive Polynomial Chaos Method (IPCM). Sensitivity equations are formulated for key input parameters, such as viscosity and thermal diffusivity, and solved numerically using the Finite Element‐Volume method.
N. Nouaime, B. Després, M. A. Puscas, C. Fiorini   +3 more
wiley   +1 more source

Direct Numerical Simulation of Magnetohydrodynamic Slip‐Flow Past a Stretching Surface Using Physics‐Informed Neural Network

Heat Transfer, EarlyView.
ABSTRACT Traditional numerical methods, such as finite difference methods (FDM), finite element methods (FEM), and spectral methods, often face meshing challenges and high computational cost for solving nonlinear coupled differential equations. Machine learning techniques, specifically Physics‐informed machine learning, address these obstacles by ...
Ahmad, Feroz Soomro, Husna Zafar
wiley   +1 more source

A new technique in constructing closed‐form solutions for nonlinear PDEs appearing in fluid mechanics and gas dynamics [PDF]

, 1996
D.E. Panayotounakos
openalex   +1 more source

Coping Practices of Small‐ and Medium‐Sized Enterprises Facing Power Asymmetry in Digital Platform Business

Strategic Change, EarlyView.
ABSTRACT Digital platform (DP) enterprises have risen to the top of the global economy by inverting traditional business models. They earn money through matchmaking, transaction facilitation, and efficient orchestration of other stakeholders' resources.
Lukas R. G. Fitz, Jochen Scheeg
wiley   +1 more source

Are physiological oscillations physiological?

The Journal of Physiology, EarlyView., 2023
Abstract figure legend Mechanisms and functions of physiological oscillations. Abstract Despite widespread and striking examples of physiological oscillations, their functional role is often unclear. Even glycolysis, the paradigm example of oscillatory biochemistry, has seen questions about its oscillatory function.
Lingyun (Ivy) Xiong, Alan Garfinkel
wiley   +1 more source

New Biologic and Small Molecule Therapies for Hidradenitis Suppurativa

JEADV Clinical Practice, EarlyView.
ABSTRACT Hidradenitis suppurativa (HS) is an inflammatory skin disease that has historically been underdiagnosed and, until recently, under‐researched. Furthermore, the pathophysiology of HS is complex, and not fully understood. Just three biologic medications—adalimumab (anti‐TNF‐α), secukinumab (anti‐IL17A) and bimekizumab (anti‐IL17A/F) are licensed
Emily Pender, Rosalind Hughes, Brian Kirby   +2 more
wiley   +1 more source

Using physics‐informed neural networks to quantify submarine groundwater discharge under high‐frequency tidal dynamics using heat as a tracer

Limnology and Oceanography: Methods, EarlyView.
Abstract Estimating exchange rates of submarine groundwater discharge (SGD) at high temporal resolution over extended periods remains challenging, particularly when using heat as a tracer in highly dynamic environments such as tidal systems. Currently available heat transport models struggle to accurately quantify SGD exchange rates in these settings ...
S. Frei, M. U. Munir, A. M. Seiverth, B. S. Gilfedder   +3 more
wiley   +1 more source