Results 91 to 100 of about 16,107,577 (322)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Solvability of generalized monomial groups [PDF]

Journal of Group Theory, 2010
The solvability of monomial groups is a well-known result in character theory. Certain properties of Artin L-series suggest a generalization of these groups, namely to such groups where every irreducible character has some multiple which is induced from a character phi of U with solvable factor group U/ker(phi).
openaire   +3 more sources

Export of miRNAs from activated macrophages is cooperative and HuR‐dependent

FEBS Letters, EarlyView.
This study uncovers a new mechanism for miRNA export regulation in mammalian cells, driven by the RNA‐binding protein HuR. In macrophages, HuR cooperatively binds with miRNAs to export both low‐ and high‐affinity substrates, thereby influencing macrophage activation.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Lifting in Frattini Covers and A Characterization of Finite Solvable Groups [PDF]

, 2011
We prove a lifting theorem for odd Frattini covers of finite groups. Using this, we characterize solvable groups and more generally p-solvable groups in terms of containing a triple of elements of distinct prime power orders with product 1.
R. Guralnick, P. Tiep
semanticscholar   +1 more source

Jordan’s theorem for solvable groups [PDF]

Proceedings of the American Mathematical Society, 1970
We show that every finite solvable group of n × n n \times n matrices over the complex numbers has a normal abelian subgroup of index ≦ 2 4 n / 3 − 1
openaire   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Solvable Groups and Loops

Journal of Algebra, 1996
Let \(Q\) be a loop and \(M(Q)\) be its multiplication group, i.e. the subgroup of the symmetric group \(S_Q\) generated by all the left and right translations. And moreover, let us assume that there exists a series of subloops of the loop \(Q\) of the form \(1=Q_0\leq Q_1\leq\cdots\leq Q_n=Q\), where \(Q_i\) is a normal subloop in \(Q_{i-1}\) and ...
openaire   +1 more source

2-KNOTS WITH SOLVABLE GROUPS [PDF]

Journal of Knot Theory and Its Ramifications, 2011
We show that fibered 2-knots with closed fiber the Hantzsche–Wendt flat 3-manifold are not reflexive, while every fibered 2-knot with closed fiber a Nil-manifold with base orbifold S(3, 3, 3) is reflexive. We also determine when the knots are amphicheiral or invertible, and give explicit representatives for the possible meridians (up to automorphisms ...
openaire   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source