Results 91 to 100 of about 5,422,708 (286)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Non-Solvable Groups whose all Vanishing Class Sizes are Odd-Square-Free [PDF]

Advances in Group Theory and Applications
Given a finite group G, a vanishing element is an element x ∈ G for which there exists χ ∈ Irr(G) such that χ(x) = 0. The conjugacy class of a vanishing element is called a vanishing class of G. Considering G as a finite non-solvable group with Sol(G) as
Roghayeh Hafezieh, Gülsemin Çonoğlu
doaj   +1 more source

On solvable groups

Mathematische Annalen, 1986
Some properties of H. C. Wang's splitting are investigated. We look into some applications of L. Auslander's semisimple splitting and derive some splittings based on the same idea. In the last part of the paper, full subgroups of simply connected solvable analytic groups whose exponential maps are bijective are studied.
Chen, P.B., Wu, T.S.
openaire   +2 more sources

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Finite non-solvable groups with few sum of numbers of Sylow subgroups [PDF]

European Journal of Mathematics and Applications
Let $G$ be a finite group and $n_p(G)$ be the number of Sylow $p$-subgroups of $G$. Let $S(G)=\{p\in \pi(G) \colon n_p(G)>1 \}$ and define $\delta_0(G)=\sum_{p \in S(G)}n_p(G)$. Denote by $Sol(G)$ the solvable radical.
Tingting Li
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

The Frattini p-subalgebra of a solvable Lie p-algebra [PDF]

, 1997
In this paper we continue our study of the Frattini p-subalgebra of a Lie p-algebra L. We show first that if L is solvable then its Frattini p-subalgebra is an ideal of L. We then consider Lie p-algebras L in which L^2 is nilpotent and find necessary and
Towers, David, Lincoln, Mark
core   +2 more sources

Exactly solvable quantum few-body systems associated with the symmetries of the three-dimensional and four-dimensional icosahedra

SciPost Physics, 2016
The purpose of this article is to demonstrate that non-crystallographic reflection groups can be used to build new solvable quantum particle systems. We explicitly construct a one-parametric family of solvable four-body systems on a line, related to ...
T. Scoquart, J. J. Seaward, S. G. Jackson, M. Olshanii
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source