Results 81 to 90 of about 2,105 (253)

Solvability of a close to symmetric system of difference equations

Electronic Journal of Differential Equations, 2016
Summary: The problem of solvability of a close to symmetric product-type system of difference equations of second order is investigated. Some recent results in the literature are extended.
Stevič, Stevo, Iričanin, Bratislav, Šmarda, Zdeněk   +2 more
openaire   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A new class of solvable nonlinear difference equation systems

, 2021
The paper deals with the following system of nonlinear difference equations \begin{equation*} x_{n+1}=ax_{n}^{2}y_{n}+bx_{n}y_{n}^{2},\ y_{n+1}=cx_{n}^{2}y_{n}+dx_{n}y_{n}^{2},\ n\in \mathbb{N}_{0}, \end{equation*} where the initial values $x_{0},y_{0}$ and the parameters $a$, $b$, $c$, $d$ are arbitrary real numbers, which is a new class of solvable ...
openaire   +2 more sources

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Global behavior of a third order rational difference equation [PDF]

, 2006
summary:In this paper, we determine the forbidden set and give an explicit formula for the solutions of the difference equation $$x_{n+1}=\frac {ax_{n}x_{n-1}}{-bx_{n}+ cx_{n-2}},\quad n\in \mathbb {N}_0 $$ where $a$, $b$, $c$ are positive real numbers ...
Aloqeili, Marwan, Abo-Zeid, Raafat
core   +1 more source

On a solvable symmetric and a cyclic system of partial difference equations

Filomat, 2018
It is shown that the following symmetric system of partial difference equations cm,n = dm-1,n + cm-1, n-1, dm,n = cm-1,n + dm-1,n-1, is solvable on the combinatorial domain C = n {(m,n) ? N20 : 0 ? n ? m}\{(0,0)}, by presenting some formulas for the general solution to the system on the domain in terms of the boundary values cj,j, cj,0, dj,j ...
Stević, Stevo, Iričanin, Bratislav, Šmarda, Zdeněk   +2 more
openaire   +3 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Solvability of a class of product-type systems of difference equations [PDF]

Advances in Difference Equations, 2016
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source