Results 51 to 60 of about 2,011 (265)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Calculation of Liquidity, Solvency and Profitability Ratio in Manufacturing Company

Journal of Applied Accounting and Taxation, 2018
This research discuss the calculation of liquidity, solvency and profitability ratios. The liquidity ratio is the ratio that describes the company's ability to meet short-term liabilities, solvency ratio is the ratio that describes the company's ability to meet long-term obligations and the profitability ratio is the ratio that measures the company's ...
Shinta Wahyu Hati, Rally Ferry Agusta
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

PENGARUH LIKUIDITAS, SOLVABILITAS DAN BIAYA BUNGA TERHADAP PROFITABILITAS DI KOPERASI SERBA USAHA SEDANA GRAHA SESETAN DENPASAR PERIODE 2013-2019

Jurnal Ilmiah Manajemen dan Bisnis, 2021
This study aims to examine the effect of liquidity, solvency, and interest costs on profitability in the all-purpose cooperative Sedana Graha Sesetan Denpasar.
Gusti Alit Suputra
doaj  

ANALYSIS OF SOLVENCY RATIO AND PROFITABILITY RATIO TO STOCK RETURN

This research is a quantitative descriptive research using secondary data collectionthrough documentation. The sample consisted of 13 health companies listed on the IndonesiaStock Exchange in 2020 - 2022, which were obtained by purposive sampling. The dataanalysis method used is the multiple regression analysis method.
Dian, Pratiwi, Warjono, Francisca Olivine Wardiyanti, Olivine Wardiyanti   +2 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

ANALISIS LAPORAN KEUANGAN DARI TAHUN 2013-2015 PADA KOPERASI KARTIKA D-10/GABUNGAN AJEN KOREM 074/WARASTRATAMA SURAKARTA

Jurnal Kewirausahaan dan Bisnis, 2017
The purpose of the study is to determine the financial performance of the Cooperative Kartika D-10/Gabungan Ajen Korem 074 Warastrama Surakarta in the period of 2013-2015 in terms of the ratios of liquidity, solvency, and profitability.
Budi Joko Santosa
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Corporate Governance's Role in Shaping Tax Avoidance Strategies [PDF]

Облік і фінанси
Companies are increasingly resorting to tax avoidance, a strategy aimed at reducing the tax burden within the law, to accumulate more capital. Understanding the drivers of tax avoidance is crucial for both regulatory bodies and businesses, particularly ...
Peter Winarta, Yuniarwati
doaj   +1 more source