Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Microwave-assisted deep eutectic solvent extraction and macroporous resin purification of anthocyanins from <i>Purple-heart Radish</i>: Process optimization, structural characterization and quantitative analysis. [PDF]
Jin P +9 more
europepmc +1 more source
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Green ultrasound‑assisted deep eutectic solvent extraction of flavonoid enzyme inhibitors from <i>Blumea aromatica</i>: process optimization, characterization, and mechanistic insights into <i>α</i>‑glucosidase and tyrosinase inhibition. [PDF]
Dai W +8 more
europepmc +1 more source
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Aliquat 336 in Solvent Extraction Chemistry of Metallic ReO4- Anions. [PDF]
Atanassova M, Petkova Z, Kurteva V.
europepmc +1 more source
Selective Extraction of Critical Metals from Spent Li‐Ion Battery Cathode: Cation–Anion Coordination and Anti‐Solvent Crystallization [PDF]
Yanqiu Lyu +9 more
openalex +1 more source
Tumor mutational burden as a determinant of metastatic dissemination patterns
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal +4 more
wiley +1 more source
Acceleration of Final Residual Solvent Extraction From Poly(lactide-co-glycolide) Microparticles. [PDF]
Kias F, Bodmeier R.
europepmc +1 more source

