Results 91 to 100 of about 863,403 (336)

Optimizing Total Quality Management (TQM) Principles as a Strategy for Educational Transformation Towards the Golden Generation 2045

Journal of Education for Sustainability and Diversity
Improving the quality of education is needed by developing human resources as an effort to prepare a superior generation of 2045, one of which is by paying attention to the implementation of TQM principles in schools.
Vika Ardianti, Sumiatun Sumiatun, Mustiningsih Mustiningsih, Rochmawati Rochmawati, Jun Solver Camara   +4 more
doaj   +1 more source

Improvement of the prediction of surface ozone concentration over conterminous U.S. by a computationally efficient second‐order Rosenbrock solver in CAM4‐Chem

Journal of Advances in Modeling Earth Systems, 2017
The global chemistry‐climate model (CAM4‐Chem) overestimates the surface ozone concentration over the conterminous U.S. (CONUS). Reasons for this positive bias include emission, meteorology, chemical mechanism, and solver.
Jian Sun, Joshua S. Fu, John Drake, Jean‐Francois Lamarque, Simone Tilmes, Francis Vitt   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Coupling problem in thermal systems simulations [PDF]

, 2017
Building energy simulation is playing a key role in building design in order to reduce the energy consumption and, consequently, the CO2 emissions. An object-oriented tool called NEST is used to simulate all the phenomena that appear in a building.
González Esteve, Adrià
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

From Portfolio Solvers to Agentic Solvers

This paper explores the shift from traditional portfolio solvers to agentic solvers, enabled by Large Language Models (LLMs) to support autonomous and collaborative behavior across solving systems. Beyond per-instance algorithm selection, agentic solvers can dynamically adapt strategies, refine solutions, and reformulate models.
AMADINI, ROBERTO, Gazza, Simone
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Stochastic 2D Incompressible Navier-Stokes Solver Using the Vorticity-Stream Function Formulation

Journal of Applied Mathematics, 2013
A two-dimensional stochastic solver for the incompressible Navier-Stokes equations is developed. The vorticity-stream function formulation is considered.
Mohamed A. El-Beltagy, Mohamed I. Wafa
doaj   +1 more source

Preconditioned conjugate-gradient methods for low-speed flow calculations [PDF]

An investigation is conducted into the viability of using a generalized Conjugate Gradient-like method as an iterative solver to obtain steady-state solutions of very low-speed fluid flow problems.
Ajmani, Kumud, Liou, Meng-Sing, Ng, Wing-Fai   +2 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source