Results 191 to 200 of about 863,403 (336)

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

Numerical Validation of mSOUND Using Fully Heterogeneous Skull Models. [PDF]

IEEE Open J Ultrason Ferroelectr Freq Control
Bell J, Xu LU, Chen H, Jing Y.
europepmc   +1 more source

A Non-Iteration Solution for Solving the Backward-in-Time Two-Dimensional Burgers’ equation with a Large Reynolds Number

, 2022
Yen-Shen Chang, Yung-Wei Chen, Chein‐Shan Liu, Jiang‐Ren Chang   +3 more
openalex   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Isogeometric suitable coupling methods for partitioned multiphysics simulation with application to fluid-structure interaction. [PDF]

Eng Comput
Li JY, Verhelst HM, den Besten H, Möller M.   +3 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Comparative Analysis of Open-Source Finite Element Method Solvers for Computational Fluid Dynamics Performance in a Carotid Artery Model. [PDF]

J Biomech Eng
Throop A, Sudbury N, Timmins LH, Baradaran H, Weiss JA, Arzani A.   +5 more
europepmc   +1 more source

Solving the Many-Body Polarization Problem on GPUs: Application to MOFs [PDF]

, 2013
Brant Tudor, Brian Space
openalex   +1 more source

Evaluation of an MSO-Solver [PDF]

, 2012
Alexander Langer, Felix Reidl, Peter Rossmanith, Somnath Sikdar   +3 more
openaire   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source