Results 81 to 90 of about 863,403 (336)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Numerical and analytical investigation of subcycling in the flow problem of a strongly-coupled partitioned fluid-structure interaction simulation [PDF]

, 2019
Fluid-structure interaction (FSI) simulations can be used to quantify the frequency, damping constant and amplitude of the vibration of equipment such as piping and heat exchangers.
De Moerloose, Laurent, Degroote, Joris
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

FEATURES OF PROGRAM-METHODICAL COMPLEX "TERRA MATH”.

Ìнформаційні технології в освіті, 2010
The problems of creation, dissemination, implementation and maintenance of program-methodical complex TerraMathematica. The architecture, methodology content, product features are showed.
V.S. Kruglik
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An Integrated Computational Approach for Optimizing Wageningen B-Series Marine Propellers and Assessing Open Water Performance through CFD Simulation

Wave
This study investigates the optimization of Wageningen B-series marine propellers using a CFD-based approach combined with numerical solver techniques to improve hydrodynamic performance under operational constraints.
Muhammad Ali Reza, Lilik Khoiriyah, Muhammad Fiky Izzulhaq, Intan Rahmahwati, Vena Rizky Pusparani, Chezta Ahmad Muzakky   +5 more
doaj   +1 more source

Advanced ventricular arrhythmia ablation: step-by-step problem-solving [PDF]

, 2023
Babak Nazer
openalex   +1 more source

Numerical PDE solvers outperform neural PDE solvers

CoRR
We present DeepFDM, a differentiable finite-difference framework for learning spatially varying coefficients in time-dependent partial differential equations (PDEs). By embedding a classical forward-Euler discretization into a convolutional architecture, DeepFDM enforces stability and first-order convergence via CFL-compliant coefficient ...
Patrick Chatain, Michael Rizvi-Martel, Guillaume Rabusseau, Adam Oberman   +3 more
openaire   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source