Results 91 to 100 of about 144,411 (289)

Entorhinal Astrocyte Transplants Restore Spatial Exploration and Alleviate Amyloid‐Beta Pathology in Alzheimer's Mice

Advanced Science, EarlyView.
Impaired MEC astrocytic Ca2+ signaling is associated with fragmented spatial exploration in AD mice. Region‐specific glial progenitor transplantation generates engrafted astrocytes that are accompanied by improved AQP4 polarization, reduced amyloid‐β‐associated pathology, attenuated neuroinflammation, preserved synaptic integrity, and ameliorated ...
Fengjuan Wu, Jihua Fan, Xiang Zhou, Zhiqi Yang, Mingyue Gong, Mingzhu Huang, Zhenlu Cai, Shaofan Yang, Teng Teng, Chuanyan Yang, Jin Li, Haoyu Wang, Shuangshuang Dai, Chunhai Chen, Xiaowei Chen, Manxia Wang, Kuan Zhang   +16 more
wiley   +1 more source

TRPC3‐Driven Calcium Microdomains Instruct Peripheral Nerve Regeneration With Protective Implications for Central Neurons

Advanced Science, EarlyView.
How localized Ca2+ signals orchestrate neural repair remains unclear. Here, we show that TRPC3‐driven calcium microdomains direct nerve repair by coupling spatially confined Ca2+ signals to axon regeneration. This module operates in injured peripheral neurons and correlates with neuroprotection in Parkinson's disease, revealing a spatial logic for ...
Yu Lu, Jianbo Zhao, Zhenli Xie, Yuan Wang, Ruolin Wang, Bianbian Wang, Chuhan Shen, Yali Chen, Jingyu Yao, Ziyang Li, Huadong Xu, Zuying Chai, Zhuoyu Zhang, Changhe Wang, Rong Huang   +14 more
wiley   +1 more source

Variations in dietary habits during cancer treatment: results of a cross-sectional survey

Acta Clinica Croatica
We aimed to explore variations in dietary habits in cancer patients according to clinical and demographic characteristics. We conducted a cross-sectional survey on cancer patients treated with systemic therapy.
Sana Ennouri, Nouha Daoud, Yosra Berrazegua, Houda El Benna, Sinene Korbi, Haifa Rachdi, Nesrine Mejri, Soumaya Labidi, Hammouda Boussen   +8 more
doaj   +1 more source

piRNA-mediated regulation of transposon alternative splicing in soma and germline

Nature, 2017
Transposable elements can drive genome evolution, but their enhanced activity is detrimental to the host and therefore must be tightly regulated. The Piwi-interacting small RNA (piRNA) pathway is vital for the regulation of transposable elements, by ...
F. K. Teixeira, M. Okuniewska, C. Malone, Rémi-Xavier Coux, D. Rio, R. Lehmann   +5 more
semanticscholar   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Building Grantee Capacity as a Core Strategy to Improve Local Food Systems

Journal of Agriculture, Food Systems, and Community Development, 2019
Greater Twin Cities United Way (GTCUW), Minnesota’s largest nongovernmental social services funder, connects local people and resources to change systems that limit our potential.
Alyssa Banks, Rebecca Saito, Margaret Adameck   +2 more
doaj   +1 more source

The computerized Soma cube

Computers & Mathematics with Applications, 1986
AbstractThe seven “Soma pieces” are produced as irregular combinations of 27 identical cubes, and may be joined to form a “Soma cube”. The position of each Soma piece is expressed mathematically, and all possible positions are studied by computer programming along with geometrical considerations. It is found that the Soma cube may be constructed in 480
Brunvoll, Jon, Cyvin, Bj∅rg, Cyvin, Einar, Cyvin, Sven, Paus, Aage, St∅levik, Martin, St∅levik, Reidar   +6 more
openaire   +1 more source

Parametric Analysis of Spiking Neurons in 16 nm Fin Field‐Effect Transistor Technology

Advanced Intelligent Discovery, EarlyView.
Energy efficient computing has driven a shift toward brain‐inspired neuromorphic hardware. This study explores the design of three distinct silicon neuron topologies implemented in 16 nm fin field‐Effect transistor technology. While the Axon‐Hillock design achieves gigahertz throughput, its functional fragility persists. The Morris–Lecar model captures
Logan Larsh, Raiyan Siddique, Sarah S. Sharif, Yaser Mike Banad   +3 more
wiley   +1 more source

Contrasting Determinants of Mutation Rates in Germline and Soma

Genetics, 2017
A number of genomic features influence regional mutation rates in germline and soma. To examine if some factors behave differently in the two tissue... Recent studies of somatic and germline mutations have led to the identification of a number of factors
Chen Chen, Hongjian Qi, Yufeng Shen, Joseph K. Pickrell, M. Przeworski   +4 more
semanticscholar   +1 more source

Multi‐Property Machine Learning Models to Accelerate the Transition Toward Bio‐Based Emulsion Polymers

Advanced Intelligent Discovery, EarlyView.
A machine learning framework simultaneously predicts four critical properties of monomers for emulsion polymerization: propagation rate constant, reactivity ratios, glass transition temperature, and water solubility. These tools can be used to systematically identify viable bio‐based monomer pairs as replacements for conventional formulations, with ...
Kiarash Farajzadehahary, Nicholas Ballard   +1 more
wiley   +1 more source