Results 161 to 170 of about 144,411 (289)

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Visualizing cortical laminar architecture in the living human brain using next-generation ultra-high-gradient diffusion MRI. [PDF]

Commun Biol
Lee H, Ma Y, Chan KS, Krijnen EA, Eskandarian L, Bhatt A, Gerold J, Mahmutovic M, Puonti O, Zeng X, Deden Binder LJ, Fischl B, Keil B, Ramos-Llordén G, Klawiter EC, Lee HH, Huang SY.   +16 more
europepmc   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Possible Sarcopenia and Functional Decline After Colorectal or Gastric Cancer Surgery. [PDF]

Cancer Diagn Progn
Furuya N, Ando J, Murakami H, Hashimoto A, Takano Y, Soma D.   +5 more
europepmc   +1 more source

Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits

British Journal of Pharmacology, EarlyView.
Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama, Guanxiao Qi, Gabriele Radnikow, Danqing Yang, Dirk Feldmeyer   +4 more
wiley   +1 more source

Superioridad clínica de la apendicectomía laparoscópica sobre la técnica abierta: ¿adopción lenta de un nuevo estándar de tratamiento?

Revista Colombiana de Cirugía
Introducción. La apendicectomía es uno de los procedimientos que más practican los cirujanos generales. La tendencia actual es hacia un mayor uso de la técnica laparoscópica, sin embargo, su aplicación rutinaria es aún controvertida. Objetivo.
Juan Pablo Toro, Óscar Javier Barrera, Carlos Hernando Morales   +2 more
doaj  

Patch-Clamp Single-Cell Proteomics in Acute Brain Slices: A Framework for Recording, Retrieval, and Interpretation. [PDF]

ACS Chem Neurosci
Rodriguez L, Diedrich J, Sun L, Tsu B, Kairs S, Vlkolinsky R, Barnes CA, Martins AMA, Roberto M, Yates JR.   +9 more
europepmc   +1 more source

Comprehensive in vitro profiling of traditional and emerging stimulants at monoamine transporters and the 5‐HT2A receptor

British Journal of Pharmacology, EarlyView.
A pharmacological profiling of 58 synthetic stimulants of various classes at dopamine, norepinephrine, and serotonin transporters and the 5‐HT2A receptor, most showing distinct class‐dependent profiles, with some indicating a high abuse potential. Background and Purpose New psychoactive substances (NPSs) often emerge on the illicit drug market with ...
Darta Stalberga, Robert Kronstrand, Bianca Schranz, Nick van Zijl, Sebastian Karlman, Soma Aref, Tobias Rautio, Svante Vikingsson, Mattias Persson, Henrik Green   +9 more
wiley   +1 more source

The fitness costs of reproductive specialization scale inversely with organismal size. [PDF]

Proc Natl Acad Sci U S A
Zhang C, Libby E, Burnetti A, Herron MD, Ratcliff WC.   +4 more
europepmc   +1 more source

Subregion‐specific perineuronal net remodelling in the dorsal hippocampus drives vulnerability and resilience to chronic stress: The role of venlafaxine treatment

British Journal of Pharmacology, EarlyView.
Background and Purpose Neuronal plasticity enables the brain to adapt to internal and external demands by dynamically regulating synaptic connectivity and emotional circuitry. Impaired neuroplasticity represents a core pathophysiological framework of major depressive disorder, one of the leading causes of disability worldwide. Chronic stress is a major
Paola Brivio, Arianna Palumbo, Maria Teresa Gallo, Filippo Umberto Tancredi Veronesi, Giorgia Cortinovis, Piotr Gruca, Magdalena Lason, Ewa Litwa, Dominika Biala, Fabio Fumagalli, Mariusz Papp, Francesca Calabrese   +11 more
wiley   +1 more source