Results 91 to 100 of about 33,566 (233)

The Support design of drives in soft ground at Soma-Işıklar colliery

, 2021
Yumuşak formasyonlar içerisinde (Örneğin kil gibi) açılan galeriler çok sık tamir ve tarama gerektirecek şekilde, yüksek kabarma basınçları etkisi ile önemli ölçüde deform asyonlara uğrarlar. Bu nedenle, kabaran formasyonlarda açılan galerilerde uygulanacak olan tahkimat sistemleri ve etki eden kayaç basınçları ile ilgili detaylı araştırmalar yapmak ...
openaire   +1 more source

The morphological affinities of the fossil cranium from Kabua, Kenya Affinités morphologiques du crâne fossile de Kabua (Kenya)

Journal of the Royal Anthropological Institute, EarlyView.
Our current understanding of the origins of Homo sapiens is limited, in part, by the fragmented fossil record from Late Pleistocene and early Holocene Africa. Here, we re‐examine the Kabua 1 cranium, an enigmatic and little‐studied Kenyan fossil discovered in the 1950s. We compare virtual reconstructions created previously by our team with a wide range
Abel Marinus Bosman, Laura Tabitha Buck, Hugo Reyes‐Centeno, Marta Mirazón Lahr, Chris Stringer, Rainer Grün, Qingfeng Shao, Katerina Harvati   +7 more
wiley   +1 more source

Geological Substrate Is Related to Tooth Senescence and Population Dynamic: The Case Study of Alpine Chamois (Rupicapra rupicapra L.)

Integrative Zoology, EarlyView.
In Alpine chamois, the complete wear of the first molar coincides with the beginning of senescence and the progress of tooth wear on calcareous substrate is slower than the one on other substrates, increasing life expectancy. Thus, the first molar wear may actually be considered as an effective descriptor of senescence stage.
Roberta Chirichella, Marco Apollonio
wiley   +1 more source

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

Exploring Experiential Qualities of Relaxation in ASMR through Soma Design

, 2022
Media designad för att framkalla ASMR har använts i flera år för avslappning och bättre sömn. Ny forskning har visat att upplevd ASMR sänker stressmarkörer, och kan leda till ett avslappnat tillstånd. I detta examensarbete utforskades användandet av ASMR i en somaestetisk designprocess för att definera experientiella kvalitéer av avslappning ...
openaire   +1 more source

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

Functional organization of dendritic spines in mouse visual cortex layer 2/3 neurons. [PDF]

iScience
Jenks KR, Heller GR, Tsimring K, Martin KB, Rizvi A, Kan Ip JP, Sur M.   +6 more
europepmc   +1 more source

The E‐cadherin‐Wnt‐mir‐994 Axis Repurposes a Cadherin Switch for Niche Robustness and Germline Stem Cell Maintenance

Cell Proliferation, EarlyView.
In the Drosophila ovarian niche, an E‐cadherin‐to‐N‐cadherin switch, mediated by Wnt‐mir‐994 signalling, is repurposed to ensure niche resilience. This compensatory mechanism maintains niche integrity and stem cell support upon E‐cadherin loss, revealing a robustness circuit.
Renjun Tu, Hiu Laam Yau, Runzhi Deng, Sarah E. Webb, Shiyuan Chen, Jianquan Ni, Ting Xie   +6 more
wiley   +1 more source

Pronounced Neuroplasticity in the Primary Visual Cortex of the 13-Lined Ground Squirrel during Hibernation. [PDF]

J Neurosci
Fultz A, Mejias-Aponte CA, Jacob C, Castillo L, Nadal-Nicolas FM, Gao Y, Li W, Nienborg H.   +7 more
europepmc   +1 more source