Results 61 to 70 of about 195,550 (169)

Continuous volumetric imaging via an optical phase-locked ultrasound lens

, 2016
In vivo imaging at high spatiotemporal resolution is key to the understanding of complex biological systems. We integrated an optical phase-locked ultrasound lens into a two-photon fluorescence microscope and achieved microsecond-scale axial scanning ...
Cui, M., Germain, R., Kong, L., Lin, C., Little, J., Lämmermann, T., Tang, J., Yu, Y.   +7 more
core   +1 more source

Anchored FRET sensors detect local caspase activation prior to neuronal degeneration

Molecular Neurodegeneration, 2011
Background Recent studies indicate local caspase activation in dendrites or axons during development and in neurodegenerative disorders such as Alzheimer's disease (AD).
Samuelsson Malin, Gatsinzi Tom, Ramberg Veronica, Figueroa Ricardo A, Zhang Mu, Iverfeldt Kerstin, Hallberg Einar   +6 more
doaj   +1 more source

Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons [PDF]

, 2019
Huntington\u27s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs).
Carrillo-Reid, Luis, Chan, C Savio, Chen, Yu, Day, Michelle, Guzman, Jaime N, Ilijic, Ema, Kaplitt, Michael, Kondapalli, Jyothisri, Kress, Geraldine J, Melendez, Alexandria E, Plotkin, Joshua L, Surmeier, D James, Wokosin, David L, Xie, Zhong   +13 more
core   +1 more source

Body Maps: A Generative Tool for Soma-based Design [PDF]

Sixteenth International Conference on Tangible, Embedded, and Embodied Interaction, 2022
Karen Anne Cochrane, Kristina Mah, Anna Ståhl, Claudia Núñez-Pacheco, Madeline Balaam, Naseem Ahmadpour, Lian Loke   +6 more
openaire   +1 more source

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis. [PDF]

, 2015
ObjectiveTofacitinib is an oral Janus kinase (JAK) inhibitor for the treatment of rheumatoid arthritis (RA). The pathways affected by tofacitinib and the effects on gene expression in situ are unknown.
Boyle, DL, Bradley, J, Firestein, GS, Hodge, J, Kaplan, I, Kavanaugh, A, Krishnaswami, S, Luo, Z, Mandel, D, Mease, P, Rosengren, S, Shurmur, R, Singhal, AK, Soma, K, Wei, N   +14 more
core  

Neural network-inspired hybrid aerogel boosting solar thermal storage and microwave absorption

Nano Research Energy
In response to the rapid development of highly integrated multifunctional electronic devices, developing advanced multifunctional composite phase change materials (PCMs) that integrate thermal management, solar-thermal conversion and microwave absorption
Yang Li, Panpan Liu, Peicheng Li, Yuhao Feng, Yan Gao, Xuemei Diao, Xiao Chen, Ge Wang   +7 more
doaj   +1 more source

Five Political Provocations for Soma Design: A Relational Perspective on Emotion and Politics

Proceedings of the Halfway to the Future Symposium
Soma design is intimately entangled with the politics, not only of design itself, but of bodies. We combine perspectives from soma design, political theory, and Sara Ahmed’s work The Cultural Politics of Emotions, to develop five political provocations that reflect on the politics of soma design and the possibilities and frictions therein.
Rachael Garrett, Pasko Kisić-Merino, Claudia Núñez-Pacheco, Pedro Sanches, Kristina Höök   +4 more
openaire   +4 more sources

Assessment of Brain-Derived Neurotrophic Factor on Retinal Structure and Visual Function in Rodent Models of Optic Nerve Crush

Pharmaceuticals
The effects of brain-derived neurotrophic factor (BDNF) on retinal ganglion cell (RGC) survival and visual function were assessed in rat and mouse models of optic nerve (ON) crush.
Takazumi Taniguchi, Najam A. Sharif, Takashi Ota, Rafal A. Farjo, Rebecca Rausch   +4 more
doaj   +1 more source

Protocol for fabrication and utilization of the device for axon-cancer cell interaction testing

STAR Protocols
Summary: The device for axon and cancer cell interaction testing (DACIT) mimics neuron-cancer interactions by compartmentalizing neuron soma and axons. Here, we present a protocol to design, fabricate, load, and image the DACIT.
Ines Velazquez-Quesada, Kara Allison, Vahid Alizadeh, Erkan Tüzel, Bojana Gligorijevic   +4 more
doaj   +1 more source

Development and validation of a questionnaire (SOMA-Q) to assess ojus in manasroga

Ancient Science of Life
Background: Ojus in Ayurveda refers to the unique functioning state of bodily tissues favoring survival and homeostasis. Functional decline in ojus (ojakṣaya) is recognized in Ayurveda as a candidate causative factor for the incidence and progression of ...
H Febin, Jithesh Madhavan, Nair Pratibha
doaj   +1 more source