Results 31 to 40 of about 10,841,366 (345)

Somatic cell reprogramming-free generation of genetically modified pigs

Science Advances, 2016
A new and highly efficient method for generating mutant pigs by electroporating the CRISPR/Cas9 system into zygotes. Genetically modified pigs for biomedical applications have been mainly generated using the somatic cell nuclear transfer technique ...
F. Tanihara, T. Takemoto, Eri Kitagawa, Shengbin Rao, L. Do, A. Onishi, Y. Yamashita, Chisato Kosugi, Hitomi Suzuki, S. Sembon, Shun'ichi Suzuki, M. Nakai, Masakazu Hashimoto, A. Yasue, M. Matsuhisa, S. Noji, T. Fujimura, D. Fuchimoto, T. Otoi   +18 more
semanticscholar   +1 more source

PRESANTATION OF A FAST TECHNICS FOR THE DESCRIPTION OF THE CHROMOSOMIC CHART OF A VEGETABLE SPECIES [PDF]

Journal of Central European Agriculture, 2004
The caryologic technics aim to determine the level of polyploidy of a population or a species. The information brought for the knowledge of the chromosomal number of a species, is of various nature.
Maria ABDUL HUSSAIN, Kadhum ABDUL HUSSAIN   +1 more
doaj  

A Study on the Uniform Distribution and Counting Method of Raw Cow’s Milk Somatic Cells

Micromachines, 2022
The somatic cell count (SCC) in raw milk is an important basis for determining whether a cow is suffering from mastitis. To address the problem of an uneven distribution of somatic cells due to cell-adherent sedimentation, among other reasons, during ...
Wei Zhou, Xingyu Li, Wanyun Su, Hongbiao Zheng, Guangxin An, Zhilin Li, Shanshan Li   +6 more
doaj   +1 more source

The histone chaperone CAF-1 safeguards somatic cell identity

Nature, 2015
Cellular differentiation involves profound remodelling of chromatic landscapes, yet the mechanisms by which somatic cell identity is subsequently maintained remain incompletely understood.
Sihem Cheloufi, Ulrich Elling, Barbara Hopfgartner, Y. L. Jung, J. Murn, Maria Ninova, M. Hubmann, Aimee I. Badeaux, C. Ang, D. Tenen, Daniel J. Wesche, Nadezhda Abazova, Max Hogue, Nilgun Tasdemir, J. Brumbaugh, Philipp Rathert, Julian Jude, F. Ferrari, A. Blanco, M. Fellner, D. Wenzel, Marietta Zinner, Simon E. Vidal, O. Bell, M. Stadtfeld, Howard Y. Chang, G. Almouzni, S. Lowe, J. Rinn, Marius Wernig, A. Aravin, Yang Shi, P. Park, J. Penninger, J. Zuber, K. Hochedlinger   +35 more
semanticscholar   +1 more source

Contagem celular somática: relação com a composição centesimal do leite e período do ano no Estado de Goiás Somatic cell count: relationship to milk composition and period of the year in Goiás State, Brazil

Ciência Rural, 2005
Apesar de estar entre os maiores produtores de leite do país, o Estado de Goiás não tem estudos abrangentes e atualizados relativos à qualidade do leite.
Válter Ferreira Félix Bueno, Albenones José de Mesquita, Edmar Soares Nicolau, Antônio Nonato de Oliveira, Jaison Pereira de Oliveira, Rodrigo Balduíno Soares Neves, José Ricardo Garcia Mansur, Liandra Werner Thomaz   +7 more
doaj   +1 more source

Genetic Parameters of Bovine Milk Fatty Acid Profile, Yield, Composition, Total and Differential Somatic Cell Count

Animals, 2020
The growing interest of consumers for milk and dairy products of high nutritional value has pushed researchers to evaluate the feasibility of including fatty acids (FA) in selection programs to modify milk fat profile and improve its nutritional quality.
Tania Bobbo, Mauro Penasa, Martino Cassandro   +2 more
doaj   +1 more source

Transient Acquisition of Pluripotency During Somatic Cell Transdifferentiation with iPSC Reprogramming Factors

Nature Biotechnology, 2015
Somatic cells can be transdifferentiated to other cell types without passing through a pluripotent state by ectopic expression of appropriate transcription factors.
I. Maza, Inbal Caspi, Asaf Zviran, Elad Chomsky, Y. Rais, Sergey V. Viukov, Shay Geula, Jason D. Buenrostro, L. Weinberger, V. Krupalnik, Suhair Hanna, Mirie Zerbib, J. Dutton, W. Greenleaf, R'ada Massarwa, Noa Novershtern, J. Hanna   +16 more
semanticscholar   +1 more source

Distinct patterns of somatic genome alterations in lung adenocarcinomas and squamous cell carcinomas

Nature Genetics, 2016
To compare lung adenocarcinoma (ADC) and lung squamous cell carcinoma (SqCC) and to identify new drivers of lung carcinogenesis, we examined the exome sequences and copy number profiles of 660 lung ADC and 484 lung SqCC tumor–normal pairs.
Joshua D. Campbell, A. Alexandrov, Jaegil Kim, J. Wala, A. Berger, C. Pedamallu, S. Shukla, Guangwu Guo, Angela N. Brooks, Bradley A. Murray, M. Imieliński, Xin Hu, Shiyun Ling, Rehan Akbani, Mara W Rosenberg, C. Cibulskis, A. Ramachandran, E. Collisson, David J. Kwiatkowski, M. Lawrence, J. Weinstein, R. Verhaak, Catherine J. Wu, P. Hammerman, A. Cherniack, G. Getz, Jean C Jiashan Ina John A Liming Zhining Martin L Roy C Zenklusen Zhang Felau Demchok Yang Wang Ferguson T, J. Zenklusen, J. Zhang, Ina Felau, John A. Demchok, Liming Yang, Zhining Wang, M. Ferguson, R. Tarnuzzer, C. Hutter, H. Sofia, T. Pihl, Yunhu Wan, Sudha Chudamani, Jia Liu, Charlie Sun, R. Naresh, Laxmi Lolla, Ye Wu, C. Creighton, W. Rathmell, J. Auman, S. Balu, T. Bodenheimer, D. Hayes, K. Hoadley, A. Hoyle, Corbin D. Jones, S. Jefferys, S. Meng, P. Mieczkowski, Lisle E. Mose, C. Perou, J. Roach, Yan Shi, J. Simons, Tara J. Skelly, Matthew G. Soloway, Donghui Tan, Junyuan Wu, Umadevi Veluvolu, J. Parker, M. Wilkerson, L. Boice, Mei Huang, L. Thorne, M. Noble, Hailei Zhang, David I Heiman, Juok Cho, Nils Gehlenborg, G. Saksena, Douglas Voet, Pei Lin, S. Frazer, L. Chin, M. Tsao, F. Allison, D. Chadwick, T. Muley, M. Meister, H. Dienemann, R. Kucherlapati, Peter Park, Jay Bowen, J. Gastier-Foster, M. Gerken, K. Leraas, T. Lichtenberg, N. Ramirez, L. Wise, E. Zmuda, Josh M Stuart, E. Collisson, M. Peifer, David J. Kwiatkowski, Joshua D. Campbell, C. Sougnez, S. Schumacher, J. Shih, R. Beroukhim, Travis Zack, S. Gabriel, Matthew Meyerson, L. Byers, Tanja Davidsen, P. Laird, D. Weisenberger, D. J. Van Den Berg, Moiz Bootwalla, Phillip H. Lai, D. Maglinte, S. Baylin, J. Herman, Ludmila V. Danilova, L. Cope, D. Crain, Erin E. Curley, J. Gardner, Kevin R Lau, D. Mallery, S. Morris, J. Paulauskis, R. Penny, C. Shelton, T. Shelton, M. Sherman, P. Yena, G. Mills, M. Artyomov, R. Schreiber, R. Govindan, Matthew Meyerson   +138 more
semanticscholar   +1 more source

Genotyping of Transcriptomes links somatic mutations and cell identity

Nature, 2019
Defining the transcriptomic identity of malignant cells is challenging in the absence of surface markers that distinguish cancer clones from one another, or from admixed non-neoplastic cells.
Anna S. Nam, Kyu-Tae Kim, R. Chaligné, Franco Izzo, Chelston R Ang, Justin Taylor, Robert M. Myers, G. Abu-Zeinah, Ryan Brand, Nathaniel D. Omans, A. Alonso, Caroline Sheridan, Marisa Mariani, Xiaoguang Dai, E. Harrington, A. Pastore, J. Cubillos-Ruiz, W. Tam, R. Hoffman, R. Rabadán, J. Scandura, O. Abdel-Wahab, Peter Smibert, D. Landau   +23 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source