Results 81 to 90 of about 5,516,952 (257)
Change in composition and quality of milk as a function of volume of production, year period and milking systems and cooling
Semina: Ciências Agrárias, 2015 Aimed to evaluate the effect of three volumes monthly milk sales, months of year, types of coolers and milking systems on the freezing point of milk, fat percentage, somatic cell count (SCC) and bacterial count Total (CBT) milk come from producers that ...Loreno Egidio Taffarel , Patricia Barcellos Costa , Claudio Yuji Tsutsumi , Elcio Silvério Klosowski , Eduardo Fonseca Portugal , Antonio Carlos Lins +5 moredoaj +1 more sourceCD4 cell count recovery among HIV-infected patients with very advanced immunodeficiency commencing antiretroviral treatment in sub-Saharan Africa. [PDF]
, 2006 BACKGROUND: Patients accessing antiretroviral treatment (ART) programmes in sub-Saharan Africa frequently have very advanced immunodeficiency. Previous data suggest that such patients may have diminished capacity for CD4 cell count recovery.Myer, Landon, Landon Myer, Lawn Stephen D, Wood Robin, Lawn, Stephen, Linda-Gail Bekker, Lawn, Stephen D, Robin Wood, Bekker, Linda-Gail, Bekker Linda-Gail, Myer Landon, Stephen D Lawn, Wood, Robin +12 morecore +2 more sourcesCircular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk +17 morewiley +1 more sourceMultiple Loci Are Associated with White Blood Cell Phenotypes [PDF]
, 2011 White blood cell (WBC) count is a common clinical measure from complete blood count assays, and it varies widely among healthy individuals. Total WBC count and its constituent subtypes have been shown to be moderately heritable, with the heritability ...Taylor, K, Döring, Angela, Meisinger, C. (Christa), Kushang V Patel, Fox, Caroline S., Garner Stephen F., Wichmann HE, Uitterlinden AG, Taylor Kent, Witteman, JC, Wiggins Kerri L., Reiner, AP, Lin JingPing, Andrew B. Singleton, Neil A Zakai, Biffi Alessandro, Folsom, AR, Matsuda K, Völzke Henry, Kamatani Y, H.-Erich Wichmann, Pirastu Nicola, Bandinelli, S, Longo Dan L., Eiriksdottir, Gudny, Patel, K.V. (Kushang), Glazer, NL, Toshiko Tanaka, Kamatani N, Illig Thomas, Nakamura, Y. (Yusuke), Nicole L Glazer, Uitterlinden, Andre G., Toniolo, D. (Daniela), Couper, DJ, Smith, AV, Levy D, Mangino Massimo, van Rooij Frank J. A., Tsunoda T, Thein SL, Naoyuki Kamatani, Liu, Y, Ben A. Oostra, Fox Caroline S., Fox CS, Cupples L. Adrienne, Wilson, J.G. (James), Tönjes, Anke, Biffi, A. (Alessandro), Van Duijn, CM, Boerwinkle, Eric, Nalls, Michael A., Wiggins, Kerri L., Eiriksdottir, G, Smith AV, Janine F Felix, Toshihiro Tanaka, O'Donnell, CJ, Frayling, Timothy M., Wichmann, H.E. (Heinz Erich), Gasparini, P, Moore, M. (Matt), Stefania B, Boerwinkle, E, Uitterlinden, AG, Wood, Andrew R., Illig, T. (Thomas), Lettre, Guillaume, Bis, JC, Tamara B Harris, Folsom, A.R. (Aaron), Harris, T.B. (Tamara), Gieger, C, Voelker, Uwe, Levy Daniel, Meisinger, Christa, Levy, Daniel, Wiggins, K.L. (Kerri), Chen MH, Tamara B. Harris, Toniolo, D, Ouwehand, W.H. (Willem), Kazuhiko Yamamoto, Cupples, L.A. (Adrienne), Melzer, D, Lagou, Vasiliki, Couper, David J., Cornelia M van Duijn, Matsuda Koichi, Kushang V. Patel, Felix, JF, Yamamoto, K, Wilson JG, Stephen F. Garner, Kerri L, Er Teumer, Prokopenko I, Matt Moore, van Rooij, Frank J. A., Taylor, Kent, Ferrucci, L. (Luigi), Chong, S. (Sean), Sambrook J, Gieger C, Gieger Christian, Folsom Aaron R., Chong, Sean, Wood, AR, Garcia M, Garcia, M. (Melissa), Sambrook, J.G. (Jennifer), Hofman Albert, Couper, D. (David), Dan L, Sambrook, Jennifer, Nakamura Y, Wiggins, KL, Guillaume Lettre, Tatsuhiko Tsunoda, Nauck, Matthias, Abbas Dehghan, Aaron R. Folsom, Smith, A.V. (Albert Vernon), Stumvoll Michael, Lumley T, Daniela Toniolo, Völker, U. (Uwe), Willem H. Ouwehand, Rendon, A, Santhi K Ganesh, Arepalli, S, Lettre G, Illig T, Levy, D. (Daniel), Liu Y, Soranzo, N. (Nicole), Greinacher, A, Melzer, David, Thomas Illig, Völzke, H. (Henry), Nauck M, Aravinda Chakravarti, Neil A. Zakai, Andreas Greinacher, Bandinelli, Stefania, Prokopenko, Inga, O'Donnell CJ, Lettre, G, Christopher J O'Donnell, Okada, Y, Moore, Matt, Coresh Josef, Jacqueline C M Witteman, Couper David J., Nalls, M.A. (Michael), Gieger, C. (Christian), Frayling Timothy M., Garner SF, Gudnason, V. (Vilmundur), James G. Wilson, Kuhnel B, Sampath Arepalli, Mangino, M, Yamamoto, Kazuhiko, Chen, Ming-Huei, Chen, MH, Timothy M, Yang, Qiong, Yang, Q, Zakai, Neil A., Moore, M, Frayling TM, Singleton, Andrew B., Menzel, S, Koichi Matsuda, Fox, CS, Dehghan A, Tim D Spector, Takahashi A, Yang Qiong, Ferrucci, L, Garcia Melissa, Lettre Guillaume, Patel, KV, Toenjes, Anke, Thein Swee Lay, Jonathan Stephens, Willem H Ouwehand, Harris TB, Uitterlinden, A.G. (André), Felix, Janine F., Nalls MA, Alessandro Biffi, Greinacher, Andreas, Luigi Ferrucci, O'Donnell, C.J. (Christopher), Kubo Michiaki, Tönjes, A. (Anke), Aaron R Folsom, Völzke, H, Dehghan, Abbas, H-Erich Wichmann, Hofman A, Melissa Garcia, Gudnason, V, Gouskova Natalia A., Qiong Yang, Ferrucci Luigi, Reiner AP, Arepalli, Sampath, Vasiliki Lagou, Caroline S Fox, Frayling, T.M. (Timothy), Ganesh, Santhi K., Albert V Smith, Patel, Kushang V., Tsunoda, T. (Tatsuhiko), Coresh J, Cupples, LA, Lettre, G. (Guillaume), Garner, Stephen F., Bruce M Psaty, Smith, Albert V., Reiner, Alex P., Frayling, TM, Teumer, A, Stumvoll, M. (Michael), Daniel Levy, Matthias Nauck, Takahashi, A, Frank J. A. Van Rooij, Felix, J.F. (Janine), Prokisch H, Arepalli S, Hernandez, Dena G., van Duijn, Cornelia M., Atsushi Takahashi, Zakai, N.A. (Neil), Janine F. Felix, Psaty, B.M. (Bruce), Patel Kushang V., Harris, TB, Yusuke Nakamura, Cornelia M. Van Duijn, Yoichiro Kamatani, Zakai NA, Prokopenko Inga, Gouskova, N.A. (Natalia), Witteman Jacqueline C. M., Patel KV, Felix Janine F., Wichmann H.-Erich, Tikka-Kleemola, P. (Päivi), Oostra, B.A. (Ben), Tsunoda Tatsuhiko, Joshua C Bis, Stumvoll, Michael, Tim D. Spector, Lumley, Thomas, Andre ́ G. Uitterlinden, Oostra, BA, Wilson, James G., Kuhnel, B, Hofman, Albert, Zakai Neil A., Yongmei Liu, Rendon, Augusto, Eric Boerwinkle, Teumer Alexander, Yukinori Okada, André G. Uitterlinden, Glazer, Nicole L., Illig, Thomas, Dan L. Longo, Döring, A. (Angela), Biffi A, Voelzke, Henry, Völker Uwe, van Duijn Cornelia M., Oostra Ben A., Singleton AB, Wood Andrew R., Lumley Thomas, Ouwehand Willem H., Glazer Nicole L., Soranzo Nicole, Eiriksdottir Gudny, Stefania Bandinelli, Ganesh Santhi K., van Rooij FJ, Pirastu, N, Spector, TD, David J Couper, Pistis, G, Kamatani, Y. (Yoichiro), Tanaka, T, Cupples LA, Psaty BM, Dena G. Hernandez, Wichmann, H. -Erich, Arepalli Sampath, Psaty, Bruce M., Sean Chong, Kubo, M, Taylor K, Van Rooij, FJ, Wiggins KL, David Melzer, Timothy M. Frayling, Henry Völzke, Bruce M. Psaty, O'Donnell Christopher J., Menzel, Stephan; id_orcid, L. Adrienne Cupples, Chong Sean, Thein, S.L., Lin, J., Jennifer Sambrook, Santhi K. Ganesh, Kuhnel Brigitte, Yang, Q. (Qiong Fang), Gouskova, NA, Tönjes, A, Kamatani Naoyuki, Kamatani, Naoyuki, Rendon, A. (Augusto), Witteman, Jacqueline C. M., Felix JF, Wilson James G., Okada, Yukinori, Longo DL, Tanaka Toshiko, Lin J, Bis, J.C. (Joshua), Ro Biffi, Takahashi, A. (Atsushi), Longo, Dan L., JingPing Lin, Teumer, A. (Alexander), Dehghan Abbas, Folsom, Aaron R., Prokopenko, I. (Inga), Völker U, Eiriksdottir G, Liu, Y. (YongMei), Moore Matt, Ferrucci, Luigi, Soranzo, N, Longo, D.L. (Dan), Dehghan, A, Jacqueline C. M. Witteman, Caroline S. Fox, Spector, Tim D., Michael Stumvoll, Lumley, T, Wood, A.R. (Andrew), Bis JC, Witteman JC, Arepalli, S. (Sampath), Sambrook, J, Döring Angela, Biffi, A, Sambrook Jennifer, Albert V. Smith, Frank J A van Rooij, Inga Prokopenko, Menzel, Stephan, Folsom AR, Hernandez, D.G. (Dena), Stumvoll, M, Hernandez DG, Anke Tönjes, Bis Joshua C., Dena G. Hern, Kerri L. Wiggins, Timothy M Frayling, Pistis, G. (Giorgio), Tanaka Toshihiro, Vilmundur Gudnason, Meisinger, C, Doering, Angela, Nicola Pirastu, Tsunoda, Tatsuhiko, Völker, Uwe, Singleton Andrew B., O'Donnell, Christopher J., Eiriksdottir, G. (Gudny), Thein, Swee Lay, Meisinger C, Zakai, NA, van Duijn CM, Kamatani Yoichiro, Lagou V, Menzel S, Natalia A Gouskova, Coresh, J. (Josef), Kent Taylor, Prokisch, Holger, Menzel, S. (Stephan), Rendon Augusto, Mangino, Massimo, Christopher J. O’donnell, Völzke, Henry, Kamatani, N, Wichmann, HE, Coresh, Josef, Völker, U, Lin, JingPing, Kamatani, Y, Hernandez, DG, Stephens, J. (Jonathan), Alex P. Reiner, Nakamura Yusuke, Mangino M, Stephens, Jonathan, Levy, D, Boerwinkle, E.A. (Eric), Okada Yukinori, Kerri L Wiggins, Stephan Menzel, Bis, Joshua C., Tanaka, T. (Toshiko), Alex P Reiner, Tsunoda, T, Massimo Mangino, Chakravarti Aravinda, Lin, J, Thomas Lumley, Teumer, Alexander, Chakravarti, A. (Aravinda), Brigitte Kuhnel, Fox, C.S. (Caroline), Ouwehand, WH, Harris, Tamara B., Moore M, Michael A. Nalls, Stephens Jonathan, Nicole L. Glazer, Gouskova NA, Pistis, Giorgio, Illig, T, David J. Couper, Bandinelli, S. (Stefania), Stephen F Garner, Spector Tim D., Ming-Huei Chen, Toniolo, Daniela, Cupples, L. Adrienne, Gudnason V, Toniolo Daniela, Nauck Matthias, Nauck, M, Gudnason, Vilmundur, Thein, SL, Kuhnel, Brigitte, Prokopenko, I, Giorgio Pistis, Kubo, Michiaki, Melzer D, Nakamura, Yusuke, Prokisch Holger, Smith Albert V., Yamamoto Kazuhiko, Longo, DL, Ben A Oostra, Garner, SF, Liu, Yongmei, Garcia, Melissa, Christopher J. O'Donnell, Menzel Stephan, Völzke H, Gasparini, Paolo, Reiner, A.P. (Alex), Singleton, A. (Andrew), Gudnason Vilmundur, Greinacher A, Spector, T.D. (Timothy), Matsuda, Koichi, Nakamura, Y, Chen Ming-Huei, Dehghan, A. (Abbas), Stephens, J, Soranzo, Nicole, Chakravarti, A, Andrew R Wood, Boerwinkle Eric, Chong S, Hofman, A. (Albert), Dena G Hernandez, Melzer David, Biffi, Alessandro, Albert Hofman, Matsuda, K. (Koichi), Kuhnel, B. (Brigitte), Nalls, MA, Harris Tamara B., Andrew R. Wood, Prokisch, H. (Holger), Tönjes Anke, Uitterlinden André G., Pirastu, N. (Nicola), André G Uitterlinden, Melzer, D. (David), Rooij, F.J.A. (Frank) van, Meisinger Christa, Tanaka T, Greinacher, A. (Andreas), Ouwehand WH, Natalia A. Gouskova, Ganesh, S.K. (Santhi), Gieger, Christian, Kubo M, Josef Coresh, Rendon A, Ganesh SK, Nicole Soranzo, Coresh, J, Mangino, M. (Massimo), Michael A Nalls, Glazer, N.L. (Nicole), Döring A, Teumer A, Liu Yongmei, Tanaka, Toshihiro, Nalls Michael A., Chakravarti, Aravinda, Wichmann, Heinz-Erich, Toniolo D, Alexander Teumer, Nauck, M. (Matthias), Stephens J, Kubo, M. (Michiaki), Oostra, Ben A., Boerwinkle E, Christian Gieger, Kamatani, Yoichiro, Stumvoll M, Psaty, BM, Takahashi, Atsushi, Bandinelli Stefania, Wood AR, Pistis G, Spector TD, Ferrucci L, Matsuda, K, Augusto Rendon, Hernandez Dena G., Lagou Vasiliki, Oostra BA, Lagou, V, Tanaka, Toshiko, Yamamoto K, Chong, S, Willem H, Paolo Gasparini, Dan L Longo, Yamamoto, K. (Kazuhiko), Tönjes A, Andrew B Singleton, Taylor, K.D. (Kent), O'Donnell, Christopher J., Swee Lay Thein, Couper DJ, Joshua C. Bis, Hofman, A, Wilson, JG, Gasparini Paolo, Reiner Alex P., Lumley, T. (Thomas), Yang Q, Angela Döring, Singleton, AB, Gasparini, P. (Paolo), Okada, Y. (Yukinori), Garcia, M, Psaty Bruce M., Takahashi Atsushi, Bandinelli S, Döring, A, Christa Meisinger, Lagou, V. (Vasiliki), Witteman, J.C.M. (Jacqueline), Pistis Giorgio, Pirastu, Nicola, James G Wilson, Greinacher Andreas, Soranzo N, Chen, M-H. (Ming-Huei), Chakravarti A, Prokisch, H, Uwe Völker, H. -erich Wichmann, Garner, S.F. (Stephen), Gudny Eiriksdottir, Okada Y, Aaron R, L Adrienne Cupples, Gouskova, Natalia A., Glazer NL, Ganesh, SK, Ouwehand, Willem H., Holger Prokisch, Michiaki Kubo, Chen, Ming Huei, Uitterlinden, André G.; id_orcid, van Rooij, Frank J.A.; id_orcid +606 morecore +1 more sourceTranscriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel +14 morewiley +1 more sourceDevelopmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley +13 morewiley +1 more sourceFinding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer +10 morewiley +1 more source
