Results 111 to 120 of about 98,308 (251)

Validation of somatic cell score-associated SNPs from Holstein cattle in Sudanese Butana and Butana × Holstein crossbred cattle. [PDF]

Trop Anim Health Prod, 2022
Elzaki S, Korkuc P, Arends D, Reissmann M, Rahmatalla SA, Brockmann GA.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Functional germline variants together with somatic mutations alter the integrity of cancer hallmark regulatory networks

Genome Medicine
Background How germline and somatic alterations together contribute to alterations in cancer relevant pathways in individual cancers remains poorly understood.
Jiawei Dai, Mate Posta, Michal Marczyk, Tao Qing, Balazs Gyorffy, Lajos Pusztai   +5 more
doaj   +1 more source

Compositional analysis of ruminal bacteria from ewes selected for somatic cell score and milk persistency. [PDF]

PLoS One, 2021
Martinez Boggio G, Meynadier A, Daunis-I-Estadella P, Marie-Etancelin C.   +3 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Genetic parameters for milkability and somatic cell score in Slovak dairy sheep

Indian Journal of Animal Sciences, 2022
P A MAKOVICKÝ, M MARGETÍN, M NAGY, P E MAKOVICKÝ   +3 more
doaj   +1 more source

Relationships among clinical mastitis test-day records, somatic cell counts, and linear udder conformation traits in Czech dairy cows

Czech Journal of Animal Science
This study evaluated test-day records of clinical mastitis (CM), somatic cell count, and nine udder conformation traits. Somatic cell count was log-transformed into somatic cell score (SCS) in 10 periods, each 30 days long and overall, for the first ...
Jan Vařeka, Ludmila Zavadilová, Matúš Gašparík, Miloslava Štípková, Luboš Vostrý   +4 more
doaj   +1 more source

Genetic parameters and genome-wide association for milk production traits and somatic cell score in different lactation stages of Shanghai Holstein population. [PDF]

Front Genet, 2022
Liu D, Xu Z, Zhao W, Wang S, Li T, Zhu K, Liu G, Zhao X, Wang Q, Pan Y, Ma P.   +10 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source