Results 121 to 130 of about 546,473 (236)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

From root to embryogenic transition: WOX5 reprograms plant somatic cells via auxin-mediated pathways. [PDF]

BMC Plant Biol
Wójcik AM, Krypczyk K, Buchcik WM, Gaj MD.   +3 more
europepmc   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Position-dependent roles of somatic cells in phototaxis of Volvox. [PDF]

PNAS Nexus
Harada K, Komasaka Y, Yamada K, Iizuka T, Otani M, Murayama Y.   +5 more
europepmc   +1 more source

Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects. [PDF]

Stem Cell Reports, 2023
Lasry R, Maoz N, Cheng AW, Yom Tov N, Kulenkampff E, Azagury M, Yang H, Ople C, Markoulaki S, Faddah DA, Makedonski K, Orzech D, Sabag O, Jaenisch R, Buganim Y.   +14 more
europepmc   +1 more source

Beyond cytotoxic T cells: reprogrammed regulatory T cells help facilitate response to dual checkpoint blockade

Molecular Oncology, EarlyView.
Rolig, Peng, and colleagues have shed new light on how dual blockade of PD1 and LAG3 enhances antitumor immunity. They found that response to immunotherapy with anti‐PD1 + anti‐LAG3 was associated with reprogramming of canonically suppressive CD4+ regulatory T cells to an inflammatory state.
Tullia C. Bruno, Anthony R. Cillo
wiley   +1 more source

Wisent Somatic Cells Resist Reprogramming by the PiggyBac Transposon System: A Case Study Highlighting Methodological and Conservation Hurdles. [PDF]

Int J Mol Sci
Ziętek MM, Bihorac A, Wenta-Muchalska E, Duszewska AM, Olech W, Sampino S, Bernat A.   +6 more
europepmc   +1 more source

Transcriptome-wide mapping of milk somatic cells upon subclinical mastitis infection in dairy cattle. [PDF]

J Anim Sci Biotechnol, 2023
Bisutti V, Mach N, Giannuzzi D, Vanzin A, Capra E, Negrini R, Gelain ME, Cecchinato A, Ajmone-Marsan P, Pegolo S.   +9 more
europepmc   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Chemical transdifferentiation of somatic cells to neural cells: a systematic review. [PDF]

Einstein (Sao Paulo)
Visintin PV, Zampieri BL, Griesi-Oliveira K.   +2 more
europepmc   +1 more source