Results 161 to 170 of about 4,900,290 (292)

BPA-induced differential methylation of the androgen receptor promoter CpG island in medaka germline and somatic cells. [PDF]

Environ Epigenet
Giri A, Nath J, Bhandari RK.
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

The role and mechanism of estrogen/estrogen receptor α in sexual identity determination of chicken somatic cells. [PDF]

Poult Sci
Jin Z, Lin X, Wu X, Wen K, Li S, Omara A, Ge J, Gong H, Zhao M, Zhang J, Gong D, Liu L, Geng T.   +12 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Generation of functionally competent testicular somatic cells from pluripotent stem cells. [PDF]

Sci Adv
Sato T, Yoshino T, Ohtsuka M, Suzuki T, Matsumura T, Matsudaira Y, Ishikawa-Yamauchi Y, Maeda S, Yabukami H, Kanai Y, Inoue M, Shima Y, Tachibana M, Matoba S, Inoue K, Ogonuki N, Ogura A, Hayashi K, Ogawa T.   +18 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Human iPSCs derived from cryopreserved testicular somatic cells enable germline regeneration in childhood cancer survivors. [PDF]

Hum Reprod Open
Macedo T, De Guidi C, Nic Aodha L, Rao Boggavarapu N, Piechocka M, Ye X, Mastropasqua F, Keros V, Norén Nyström U, Frisk P, Johansson P, Tammimies K, Baert Y, Jahnukainen K, Stukenborg JB, Alves-Lopes JP.   +15 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

A reference genome for cultured Drosophila ovarian somatic cells enables studies of transposon and piRNA biology. [PDF]

Genome Biol
Handler D, Brennecke J.
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source